(19)

(11)

EP 1 497 426 A2

(12)

(88) Date of publication A3: 28.10.2004 (43) Date of publication: 19.01.2005 Bulletin 2005/03 (21) Application number: 02807658.6 (22) Date of filing: 21.06.2002

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/705, C12Q 1/68, A61K 38/17 (86) International application number: PCT/US2002/019898 (87) International publication number: WO 2004/029197 (08.04.2004 Gazette 2004/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.06.2001 US 888324 22.06.2001 WO PCT/US01/19973 20.12.2001 US 32214 (71) Applicant: Maxygen, Inc. Redwood City, CA 94063 (US)	(72) Inventors: PUNNONEN, Juha Belmont, CA 94002 (US) LAZETIC, Alexandra, L., L. San Jose, CA 95124 (US) LEONG, Steven, R. Berkeley, CA 94707 (US) CHANG, Jean, Chia-Chun Los Gatos, CA 95032 (US) APT, Doris Sunnyvale, CA 94086 (US) GUSTAFSSON, Claes Belmont, CA 94002 (US) (74) Representative: Salka, Jeffrey  Maxygen ApS,Agern Allé 1,Danish Science Park 2970 Hoersholm 2970 Hoersholm (DK)