(19)

(11)

EP 1 497 644 A2

(12)

(88) Date of publication A3: 12.02.2004 (43) Date of publication: 19.01.2005 Bulletin 2005/03 (21) Application number: 03728489.0 (22) Date of filing: 22.04.2003

(51) International Patent Classification (IPC)7: G01N 33/48 (86) International application number: PCT/US2003/012534 (87) International publication number: WO 2003/089905 (30.10.2003 Gazette 2003/44)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 22.04.2002 US 375150 P (71) Applicant: CDX (Oralscan) Laboratories, Inc. Suffern, NY 10901 (US)	(72) Inventors: FRIST, Stephen,CDX (Oralscan) Laboratories, Inc. Suffern, NY 10901 (US) SCOTT, Richard S. F.,CDX (Oralscan) Labs, Inc. Suffern, NY 10901 (US) (74) Representative: Richardson, Mark Jonathan et al Marks & Clerk,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)