(19)

(11)

EP 1 499 342 A2

(12)

(88) Date of publication A3: 11.11.2004 (43) Date of publication: 26.01.2005 Bulletin 2005/04 (21) Application number: 03735013.9 (22) Date of filing: 27.01.2003

(51) International Patent Classification (IPC)7: A61K 38/43, A61K 38/51, G01N 33/53, C12N 15/09, C12N 9/00, C12N 9/88 (86) International application number: PCT/US2003/002342 (87) International publication number: WO 2003/063780 (07.08.2003 Gazette 2003/32)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 25.01.2002 US 350971 P (71) Applicant: Cancer Treatments International 8006 Zürich (CH)	(72) Inventor: TEPIC, Slobodan CH-CH-8006 Zurich (CH) (74) Representative: Portal, Gérard  Cabinet Beau de Loménie158, rue de l'Université 75340 Paris Cédex 07 75340 Paris Cédex 07 (FR)