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EP 1 499 627 A2

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(88) Date of publication A3: 18.11.2004 (43) Date of publication: 26.01.2005 Bulletin 2005/04 (21) Application number: 02746811.5 (22) Date of filing: 01.07.2002

(51) International Patent Classification (IPC)7: C07H 21/02, C07H 21/04, A61K 48/00, C12Q 1/68, C12N 15/85, C12N 15/86 (86) International application number: PCT/US2002/020934 (87) International publication number: WO 2003/004602 (16.01.2003 Gazette 2003/03)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.07.2001 US 302682 P 28.11.2001 US 996292 10.12.2001 US 13295 (71) Applicant: ISIS Pharmaceuticals, Inc. Carlsbad, CA 92009 (US)	(72) Inventors: MANOHARAN, Muthiah Carlsbad, CA 92009 (US) MAIER, Martin, A. Carlsbad, CA 92009 (US) PRAKASH, Thazha, P. Carlsbad, CA 92009 (US) RAJEEV, Kallanthottathil, Gopalan Cambridge, MA 02140-2344 (US) (74) Representative: Hallybone, Huw George et al Carpmaels and Ransford,43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)