PROCESS FOR HYDROGENATING UNACTIVATED IMINES USING RUTHENIUM COMPLEXES AS CATALYSTS

Description

FIELD OF THE INVENTION

[0001] The present invention relates to the field of catalytic hydrogenations, using H₂, and more particularly to the use of a catalytic system comprising a base and a ruthenium complex containing (1) a diamine and (2) a diphosphine ligand or monodentate phosphine ligands, in hydrogenation, including asymmetric hydrogenation processes, for the reduction of unactivated imines.

BACKGROUND OF THE INVENTION

[0002] Although many highly enantioselective chiral catalysts and catalytic processes are available for the asymmetric hydrogenation and transfer hydrogenation of C=C and C=O bonds, relatively few exist for effective reduction of the analogous C=N function. The production of chiral amines via this methodology still represents a major challenge. Over the past decade, there has been significant and steady progress in this field with the preparation of catalysts based on complexes of rhodium, iridium, ruthenium and titanium.

[0003] In 1997 B.R. James reviewed the preparation of chiral amines by homogeneous catalytic hydrogenation reactions involving metal complexes (James, Catalysis Today 1997, 37, 209-221). The review by James names several other systems based on rhodium for the asymmetric hydrogenation of imines but they suffer from drawbacks. Either the enantioselectivity is low or the conditions are severe. In a recent U.S. patent, X. Zhang et al. describe the use of BICP, a chiral diphosphine ligand, on rhodium and iridium in the asymmetric hydrogenation of internal C=N bonds at 1000 psi H₂ at room temperature to produce amines with enantiomeric excesses (e.e.) ranging from 65 to 94%. (X. Zhang, US patent 6,037,500, 2000). Spindler and co-workers demonstrated the use of in situ generated iridium JOSIPHOS complexes for the enantioselective hydrogenation of imines (Spindler et al., Angew. Chem., Int. Ed. Engl., 1990, 29, 558; Blaser and Spindler, Topics in Catalysis, 1997, 4, 275). This process was subsequently modified and applied to the industrial production of the imine precursor to (S)-Metolachlor, a valuable agrichemical product, then for Ciba-Giegy, now for Novartis. The production of S-Metolachlor is an example of a large-scale industrial process that depends on the homogenous hydrogenation of a prochiral imine.

[0004] Noyori and coworkers have described an efficient catalyst system generated from the complex Ru(η⁶-arene)(tosyldiamine)Cl for the asymmetric hydrogenation of imines by transferring hydrogen from triethylammonium formate (Noyori et al., Acc. Chem. Res. 1997, 30, 97-102). This is the first really effective imine reduction system based on ruthenium although other straight hydrogenation systems with much lower activity and selectivity have been reported as reviewed by James (supra).

[0005] Buchwald and co-workers prepared and effectively employed various chiral ansa-titanocene complexes for both hydrogenation and hydrosilylation of imines (Willoughby and Buchwald, J. Am. Chem. Soc., 1992, 114, 7562; J. Am. Chem. Soc., 1994, 116, 8952 and 11703). The need to activate the catalyst by the addition of butyllithium and phenyl silane limits the scope and applicability of this process. This system also suffers from the drawback of being very oxygen and water sensitive.

[0006] A recent article by Kobayashi and Ishitani on catalytic enantioselective addition to imines also provides a comprehensive review on other advances in enantioselective hydrogenation of imines (Kobayashi and Ishitani, Chem. Rev., 1999, 99, 1069). These include the use of chiral iridium diphosphine complexes of the type [Ir(P-P)HI₂]₂ (where P-P represents a chiral diphosphine ligand) reported by Osborn and co-workers (Chan et al., J. Am. Chem. Soc., 1990, 112, 9400; Sablong et al., Tetrahedron Lett., 1996, 37, 4937). These systems were reasonably active, however, the enantioselectivities were only moderate. Zhang and co-workers reported the synthesis of a new class of chiral iridium binaphane complexes (Xiao and Zhang, Angew. Chem. Int. Ed. Engl., 2001, 40, 3425) and their use for the asymmetric hydrogenation of imines. More recently Rautenstrauch et al. (WO 02/22526) reported the use of metal complexes with P-N bidentate ligands in the catalytic hydrogenation of carbon-heteroatom double bonds, including C=N double bonds.

[0007] Despite the successes of some of these catalytic hydrogenation processes, there are certain significant drawbacks. These include high operating pressures (typically > 50 bar H₂), high catalyst loading and the use of expensive iridium- and rhodium-based systems. Most of these processes are specific for only certain types of substrates or a group of closely related substrates. In addition, activity and enantioselectivity also tends to be highly substrate dependent, which in some cases necessitates the development of an entire catalytic system and process for only one substrate or a very closely related group of substrates.

[0008] Hence, there remains the need to identify a general class of structurally related catalysts that are chemically robust and give high activity and enantioselectivity in the asymmetric hydrogenation of a broad range of imine substrates. It is particularly desirable to have a class of modular catalysts whereby one can readily vary individual parts of the catalyst, especially the chiral ligand, so that the best match of substrate and catalyst can be identified by rapid through-put combinatorial screening.

[0009] Noyori and co-workers have pioneered the use of ruthenium complexes bearing a chelating diphosphine ligand (or two monodentate phosphines) and a chelating diamine ligand for the catalytic asymmetric hydrogenation of ketones. At least one and usually both of the chelating ligands are chiral. The various papers and patents of Noyori et al. have demonstrated the highly efficient reduction of various functionalised and unfunctionalised ketones using this class of catalysts. It was also demonstrated by Noyori and co-workers (Ohkuma et al., J. Am. Chem. Soc., 1995, 107, 2675 and 10417) that a fully isolated and characterised ruthenium(II)dipliosphinediamine complex could be used as catalyst. High activity and high selectivity were generally associated with the use of chiral biaryl-phosphines (eg. Tol-BINAP and Xyl-BINAP) and diamines (eg. DPEN and DAIPEN).

[0010] It was demonstrated for the first time by Abdur-Rashid et al. that similar classes of Noyori-type ruthenium(II)(phosphine)₂(diamine) complexes (Abdur-Rashid et al., Organometallics, 2000, 20, 1655) or ruthenium(II)diphosphinediamine complexes (Abdur-Rashid et al., Oral and Poster Presentations at the Canadian Society for Chemistry 83rd Conference and Exhibition (Calgary, Alberta), May 2000) could catalyse the hydrogenation and asymmetric hydrogenation of activated (aromatic) imines. Since these publications, Chirotech Technology Limited filed a patent (WO 02/08169 AI) for an imine hydrogenation process, based on a similar class of complexes for the hydrogenation and asymmetric hydrogenation of activated (aromatic) imines. The work presented by Abdur-Rashid et al. at the May 2000 CSC meeting in Calgary was subsequently published in 2001 (Organometallics, 2001, 20, 1047).

[0011] The imine hydrogenation work of Abdur-Rashid et al. and the patent of Chirotech Technology Limited relates to the use of Noyori-type ruthenium(II)-(phosphine)₂(diamine) and ruthenium(II)diphosphinediamine complexes as catalysts for the reduction of activated imines in which the imine functional group is adjacent to an aromatic aryl ring as illustrated in (I) below.

[0012] To date, there are no reports in the mainstream or patent literature of the use of such Noyori-type ruthenium(II) complexes for the hydrogenation and asymmetric hydrogenation of unactivated dialkyl, alkylalkenyl or dialkenyl imines as illustrated in (II), where R¹ and R² represents alkyl, alkylalkenyl or dialkenyl substituents. These imines are inherently more difficult to reduce than their activated (aromatic) analogues, and there are only a few reported attempts in the published and patent literature for the catalytic hydrogenation and asymmetric hydrogenation of such compounds.

[0013] The industrial production of the chiral amine precursor to the potent herbicide S-Metolachor using an iridium-JOSIPHOS catalyst is an example of a successful process that relies on the asymmetric hydrogenation of a dialkyl imine (Togni, Angew. Chem., Int. Ed. Engl., 1996, 35, 1475).

[0014] There remains a need for efficient catalysts for the hydrogenation and asymmetric hydrogenation of unactivated imines.

SUMMARY OF THE INVENTION

[0015] The present inventors have surprisingly found that reduction or Hydrogenation of the carbon-nitrogen double bond (C=N) of dialkyl, alkylalkenyl and dialkenyl imine compounds (II) to the corresponding amines (III) can be efficiently carried out using molecular hydrogen (H₂), a base and a catalytic system comprising a ruthenium complex bearing (1) a diphosphine ligand or two monodentate phosphine ligands and (2) a diamine ligand. Such processes can also be used to achieve the asymmetric reduction/hydrogenation of prochiral dialkyl, alkylalkenyl or dialkenyl imines to the corresponding chiral amines by using chiral ruthenium complexes bearing chiral diphosphines or chiral monodentate phosphines and/or chiral diamines.

[0016] Accordingly, the present invention relates to a process for the hydrogenation and/or asymmetric hydrogenation of dialkyl, alkylalkenyl or dialkenyl imines of formula II to amines of formula III:

wherein

R¹ and R² are independently selected from the group consisting of optionally substituted cyclic, linear and branched alkyl and alkenyl and wherein R¹ and R² may also be linked together, or with R³, to form one or more rings; and

R³ is selected from the group consisting of hydrogen, hydroxy, optionally substituted C₁ to C₈ cyclic, linear and branched alkyl and alkenyl, and optionally substituted aryl;

said process comprising the steps of reacting imines of formula II in the presence of H₂ and a catalytic system comprising a base and a ruthenium complex containing (1) a diamine and (2) a diphosphine ligand or monodentate phosphine ligands.

[0017] In an embodiment, the present invention relates to a process for preparing enantiomerically enriched chiral dialkyl, alkylalkenyl or dialkenyl amines of formula III, or the opposite enantiomer thereof, from an imine of formula II:

wherein

R¹ and R² are independently selected from the group consisting of optionally substituted cyclic, linear and branched alkyl and alkenyl and wherein R¹ and R² may also be linked together, or with R³, to form one or more rings; and

R³ is selected from the group consisting of hydrogen, hydroxy, optionally substituted C₁ to C_s cyclic, linear and branched alkyl and alkenyl, and optionally substituted aryl;

said process comprising the steps of reacting imines of formula II in the presence of H₂ and a catalytic system comprising a base and a ruthenium complex containing (1) a diamine and (2) a chiral diphosphine ligand or chiral monodentate phosphine ligands. Optionally, the diamine may also be chiral.

[0018] The process involves the catalytic hydrogenation or asymmetric hydrogenation of the corresponding dialkyl, alkylalkenyl or dialkenyl imine, II, in the presence of a base using an achiral or chiral ruthenium complex containing (1) a diamine ligand and (2) an achiral or chiral diphosphine ligand or achiral or chiral monodentate phosphine ligands. In embodiments of the present invention, said ruthenium complexes may have the general formula RuXY(PR₃)₂(NH₂-Z NH₂) (IV) or RuXY(R₂P-Q-PR₂)(NH₂-Z-NH₂) (V), wherein Z and Q represent chiral or achiral linkers, the ancillary ligands, PR₃ and R₂P-Q-PR₂, represent monodentate and bidentate phosphines, respectively, and the ligands X and Y represent any anionic ligand such as Cl, Br, I, H, hydroxy, alkoxy or acyloxy. In further embodiments of the present invention, the diamine ligand may have the general formula D-Z-NHR (X), wherein D is an amido donor group.

DETAILED DESCRIPTION OF THE INVENTION

[0019] The present inventors have surprisingly found that unreactive alkyl- and alkenyl-substituted imines, which are notoriously recalcitrant to undergo hydrogenation under milder hydrogenation conditions, may be efficiently hydrogenated, as well as asymmetrically hydrogenated, in the presence of H₂ and Noyori-type ruthenium(II) complexes.

[0020] Therefore, the present invention relates to a process for the hydrogenation and/or asymmetric hydrogenation of dialkyl, alkylalkenyl or dialkenyl imines of formula II to amines of formula III:

wherein

R¹ and R² are independently selected from the group consisting of optionally substituted cyclic, linear and branched alkyl and alkenyl and wherein R¹ and R² may also be linked together, or with R³, to form one or more rings; and

R³ is selected from the group consisting of hydrogen, hydroxy, optionally substituted C₁ to C₈ cyclic, linear and branched alkyl and alkenyl, and optionally substituted aryl;

said process comprising the steps of reacting imines of formula II in the presence of H₂ and a catalytic system comprising a base and a ruthenium complex containing (1) a diamine and (2) a diphosphine ligand or monodentate phosphine ligands.

[0021] In an embodiment, the present invention relates to a process for preparing enantiomerically enriched chiral dialkyl, alkylalkenyl or dialkenyl amines of formula III, or the opposite enantiomer thereof, from an imine of formula II:

wherein

R¹ and R² are independently selected from the group consisting of optionally substituted cyclic, linear and branched alkyl and alkenyl and wherein R¹ and R² may also be linked together, or with R³, to form one or more rings; and

R³ is selected from the group consisting of hydrogen, hydroxy, optionally substituted C₁ to C₈ cyclic, linear and branched alkyl and alkenyl, and optionally substituted aryl;

said process comprising the steps of reacting imines of formula II in the presence of H₂ and a catalytic system comprising a base and a ruthenium complex containing (1) a diamine and (2) a chiral diphosphine ligand or chiral monodentate phosphine ligands. Optionally, the diamine may also be chiral.

[0022] In embodiments of the invention, said ruthenium complexes have the general formula RuXY(PR₃)₂(NH₂-Z-NH₂) (IV) or RuXY(R₂P-Q-PR₂)(NH₂Z-NH₂) (V), wherein Z and Q represent chiral or achiral linkers, the ancilliary ligands, PR₃ and R₂P-Q-PR₂, represent chrial or achrial monodentate and bidentate phosphines, respectively and the ligands X and Y represent any anionic ligand such as Cl, Br, I, H, hydroxy, alkoxy or acyloxy. These complexes, following activation with a base, catalyse the hydrogenation process.

[0023] The ligand PR₃ (VI):



        PR₃     (VI)

represents a chiral or achiral monodentate phosphine ligand wherein each R, taken separately, is independently selected from the group consisting of optionally substituted linear and branched alkyl and alkenyl containing 1 to 8 carbon atoms, optionally substituted cycloalkyl, optionally substituted aryl, or OR and NR₂, wherein R is as previously defined; or two R groups bonded to the same P atom are bonded together to form an optionally substituted saturated or aromatic ring having 5 to 8 atoms including the phosphorous atom to which said R groups are bonded.

[0024] The ligand R₂P-Q-PR₂ (VII):



        R₂P-Q-PR₂     (VII)

represents a chiral or achiral bidentate ligand wherein each R, taken separately, is independently selected from the group consisting of optionally substituted linear and branched alkyl and alkenyl containing 1 to 8 carbon atoms, optionally substituted cycloalkyl, optionally substituted aryl, or OR and NR₂, wherein R is as previously defined; or two R groups bonded to the same P atom are bonded together to form an optionally substituted saturated or aromatic ring having 5 to 8 atoms including the phosphorous atom to which said R groups are bonded; Q is selected from the group consisting of optionally substituted linear and cyclic C₂-C₇ alkylene, optionally substituted metallocenediyl and optionally substituted C₆-C₂₂ arylene.

[0025] In preferred embodiments of this invention, the diphosphine ligand is chiral and includes atropisomeric bis-tertiary phosphines, in which the two phosphorus atoms are linked by a biaryl backbone. Representative members of this class of atropisomeric compounds include BINAP, BIPHEP and BIPHEMP.

[0026] In another embodiment of this invention, the diphosphine ligand is a chiral or achiral ligand of the formula R₂P-NR'-Z-NR'-PR₂ (VIII):



        R₂P-NR'-Z-NR'-PR₂     (VIII)

wherein each R, taken separately, is independently selected from the group consisting of optionally substituted linear and branched alkyl and alkenyl containing 1 to 8 carbon atoms, optionally substituted cycloalkyl, optionally substituted aryl, or OR and NR₂, wherein R is as previously defined; or two R groups bonded to the same P atom are bonded together to form an optionally substituted saturated or aromatic ring having 5 to 8 atoms including the phosphorous atom to which said R groups are bonded; each R', taken separately, is independently selected from the group consisting of hydrogen , optionally substituted linear and branched alkyl or alkenyl containing 1 to 8 carbon atoms, optionally substituted cycloalkyl and optionally substituted aryl; Z is selected from the group consisting of optionally substituted linear and cyclic C₂-C₇ alkylene, optionally substituted metallocenediyl and optionally substituted C₆-C₂₂ arylene.

[0027] In further embodiments of the invention, the diamine ligand has the formula NH₂-Z-NH₂ (IX):



        H₂N-Z-NH₂     (IX)

wherein Z is selected from the group consisting of optionally substituted linear and cyclic C₂-C₇ alkylene, optionally substituted metallocenediyl and optionally substituted C₆-C₂₂ arylene. In preferred embodiments of the present invention, the diamine ligand is chiral and includes (1) compounds in which at least one of the amine-bearing centers is stereogenic, (2) compounds in which both of the amine-bearing centers are stereogenic and (3) atropisomeric bis-tertiary diamines, in which the two nitrogen atoms are linked by a biaryl backbone.

[0028] In another embodiment of the present invention, the coordinated amine ligand is a bidentate ligand of the type D-Z-NHR⁴ (X), which is preferably chiral, wherein Z is selected from the group consisting of optionally substituted linear and cyclic C₂-C₇ alkylene, optionally substituted metallocenediyl and optionally substituted C₆-C₂₂ arylene. Preferably, D is an amido group donor, NR⁵, thus providing an amidoamino ligand, R⁵N-Z-NHR⁴ (XI) that contains an amido group donor NR⁵ and an amino group donor NHR⁴. The substituent R⁵ may be selected from the group consisting of S(O)₂R⁶, P(O)(R⁶)₂, C(O)R⁶, C(O)N(R⁶)₂ and C(S)N(R⁶)₂ wherein the substituents R⁶, taken separately, are each independently selected from the group consisting of hydrogen, optionally substituted linear and branched alkyl and alkenyl containing 1 to 8 carbon atoms, optionally substituted cycloalkyl and optionally substituted aryl. In other embodiments, the donor group D represents a chalcogenide radical such as O, S, Se and Te. In preferred embodiments of the present invention, the coordinated amine ligand is chiral and includes (1) compounds in which the amine-bearing center is stereogenic, (2) compounds in which both the donor-bearing (D) and amine-bearing centers are stereogenic (for example the ligand CH₃C₆H4SO₃NCHPhCHPhNH₂).

[0029] The term "alkyl" as used herein means a saturated, linear or branched alkyl groups containing from one to ten, preferably one to eight, more preferably one to six carbon atoms and includes methyl, ethyl, propyl, isopropyl, s-butyl, t-butyl, neopentyl and the like. Optionally, one or more, preferably one or two, more preferably one, of the carbon atoms in an alkyl group may be substituted with a heteroatom such as O, S and N.

[0030] When R¹ and R² are linked together, or with R³, to form one or more rings, said rings may be contain from three to twelve atoms, preferably three to ten atoms, having a single ring structure or multiple condensed (fused) ring structure. Further in the rings, one or more, preferably one or two, more preferably one, of the carbon atoms may be substituted with a heteroatom such as O, S and N. An example of such a ring structure is 1-aza-bicyclo[2.2.2]oct-3-ylidene.

[0031] The term "alkylene" as used herein refer to divalent groups of the corresponding cyclic, linear or branched alkane.

[0032] The term "alkenyl" as used herein means an unsaturated, linear or branched alkenyl group containing from two to ten, preferably two to eight, more preferably two to six carbon atoms and includes vinyl, allyl, butenyl and the like and the like. The alkenyl groups may contain any number of double bonds. Preferably the alkenyl group contains one double bond.

[0033] The term "aryl" as used herein means an unsaturated aromatic carbocyclic group containing from six to fourteen carbon atoms having a single ring (e.g., phenyl) or multiple condensed (fused) rings (e.g., naphthyl or anthryl). Preferred aryls include phenyl, naphthyl and the like.

[0034] The term "cycloalkyl" or "cyclic alkyl" as used herein refers to cyclic alkyl groups of from three to twelve carbon atoms, preferably from three to eight carbon atoms, having a single cyclic ring or multiple condensed rings. Such cycloalkyl groups include, by way of example, single ring structures such as cyclopropyl, cyclobutyl, cyclopentyl, cyclooctyl, and the like, or multiple ring structures such as adamantanyl, and the like. Further in these rings, one or more, preferably one or two, more preferably one, of the carbon atoms may be substituted with a heteroatom such as O, S and N.

[0035] The term "metallocenediyl" as used herein refers to a bivalent metallocene group, typically having the following structure:

wherein M is a metal, for example iron (Fe).

[0036] The term "arylene" as used herein includes biaryldiyl groups and refers to a bivalent group comprising one to three, preferably one to two, aryl groups linked together. Examples of arylene groups include, but are not limited to biphenyldiyl and binaphthyldiyl.

[0037] The term "optionally substituted" as used herein means that the corresponding group is either unsubstituted or substituted. When a group is substituted the substituents may include one to five, preferably one to three, more preferably one to two, groups independently selected from alkyl, alkoxy, polyalkyleneglycol, carboxylic esters, OH, halo, cycloalkyl, aryl, and halo-substituted-aryl. As to any of the above groups that contain 1 or more substituents, it is understood, of course, that such groups do not contain any substitution or substitution patterns which are sterically impractical and/or synthetically non-feasible.

[0038] The term "halo" as used herein means halogen and includes chloro, flouro, bromo and iodo.

[0039] The term "alkoxy" as used herein means saturated, cyclic, linear or branched O-alkyl groups containing from one to ten, preferably one to eight, more preferably one to six carbon atoms and includes methoxy, methoxy, propoxy, t-butyloxy and the like.

[0040] The term "acyloxy" as used herein means saturated, cyclic, linear or branched O-acyl groups containing from one to ten, preferably one to eight, more preferably one to six carbon atoms and includes acetoxy and the like.

[0041] The ruthenium catalyst complexes may be prepared, for example, as described by Abdur-Rashid et al. (Organometallics, 2001, 21, 1047). Many of the ligands described above are known in the art and, unless specified differently in the Examples, are obtained according to methods known in the art. The ligands that are new can be obtained by modifying known procedures according to the knowledge of a person skilled in the art.

[0042] As previously mentioned, the catalytic system characterizing the process of the present invention comprises a base. Said base can be the substrate itself, if the latter is basic, or any conventional base. One can cite, as non-limiting examples, organic non-coordinating bases such as DBU, NR₃, phosphazene bases, alkaline or alkaline-earth metal carbonates, carboxylate salts such as sodium or potassium acetate, or alcoholates or hydroxide salts. Preferred bases are the alcoholate or hydroxide salts selected from the group consisting of the compounds of formula (R⁷O)₂M' and R⁷OM", wherein M' is an alkaline-earth metal, M" is an alkaline metal and R⁷ is selected from the group consisting of hydrogen and C₁ to C₆ linear and branched alkyl.

[0043] A typical process involves the mixture of the substrate with the ruthenium complex and a base, possibly in the presence of a solvent, and then treating such a mixture with molecular hydrogen at a chosen pressure and temperature.

[0044] The complexes can be added to the reaction medium in a large range of concentrations. As non-limiting examples, one can cite a substrate to complex (S/com) ratio of 10⁵ to 20. Preferably, the substrate to complex ratio will be in the range of 10 to 1 respectively. It goes without saying that the optimum concentration of complex will depend on the nature of the latter and on the pressure of H₂ used during the process.

[0045] Useful quantities of base, added to the reaction mixture, may be comprised in a relatively large range. One can cite, as non-limiting examples, ranges between 1 to 50000 molar equivalents relative to the complex, preferably 10 to 2000. However, it should be noted that it is also possible to add a small amount of base (e.g. base/com = 1 to 3) to achieve high hydrogenation yields.

[0046] The hydrogenation reaction can be carried out in the presence or absence of a solvent. When a solvent is required or used for practical reasons, then any solvent current in hydrogenation reactions can be used for the purposes of the invention. Non-limiting examples include aromatic solvents such as benzene, toluene or xylene, hydrocarbon solvents such as hexane or cyclohexane, ethers such as tetrahydrofuran, or yet primary or secondary alcohols, or mixtures thereof. A person skilled in the art is well able to select the solvent most convenient in each case to optimize the hydrogenation reaction.

[0047] In the hydrogenation process of the invention, the reaction can be carried out at a H₂ pressure comprised between 10⁵ Pa and 80x10⁵ Pa (1 to 80 bars). Again, a person skilled in the art is well able to adjust the pressure as a function of the catalyst load and of the dilution of the substrate in the solvent. As examples, one can cite typical pressures of 1 to 40x10⁵ Pa (1 to 40 bar).

[0048] The temperature at which the hydrogenation can be carried out is comprised between 0°C and 100°C, more preferably in the range of between 20°C and 60°C. Of course, a person skilled in the art is also able to select the preferred temperature as a function of the melting and boiling point of the starting and final products.

[0049] Preferably, the process of the present invention provides an effective means of preparing a wide range of chiral amines. It is desirable that the enantiomeric enrichment or excess (ee) of the amine (III) is at least 50% ee, and more preferably at least 80% ee, or higher. If necessary, any shortfall in ee can be subsequently corrected by crystallization techniques known by persons skilled in the art. It is also important to achieve a high conversion of substrate to product, preferably at least 80% conversion, and more preferably at least 90% conversion.

[0050] The following non-limiting examples are illustrative of the present invention:

EXAMPLES

Materials and Methods

[0051] The invention will now be described in further details by way of the following examples, wherein the temperatures are indicated in degrees centigrade and the abbreviations have the usual meaning in the art. The ligand R,R-DPPACH is a known compound that was previously used in rhodium complexes for the hydrogenation of C=C double bonds (Fioriani et al., J. Mol. Catal., 1979, 5, 303), (Onuma et al., Bull. Chem. Soc. Jpn., 1980, 53, 2012; Chem Lett., 1980, 5, 481).

[0052] All the procedures described hereafter have been carried out under an inert atmosphere unless stated otherwise. Hydrogenations were carried out in open glass tubes placed inside a stainless steel autoclave or Schlenk flasks attached to a vacuum line. H₂ gas was used as received. All preparations and manipulations were carried out under H₂, N₂ or Ar atmospheres with the use of standard Schlenk, vacuum line and glove box techniques in dry, oxygen-free solvents. Tetrahydrofuran (THF), diethyl ether (Et₂O) and hexanes were dried and distilled from sodium benzophenone ketyl. Deuterated solvents were degassed and dried over activated molecular sieves. Ruthenium trichloride, triphenylphosphine, R,R-DPEN, R,R,-CYDN, ketones and amines were purchased from Aldrich. The precursor complex RuHCl(PPh₃)₃ was prepared by a modification of the procedure reported by Schunn et al. (Inorg. Synthesis, 1970, 131). The complexes RuHCl(R-BINAP)(PPh₃), RuHCl(R,R-DPPACH)(PPh₃), RuHCl(R-BINAP)(R,R-CYDN), RuHCl(R-BINAP)(R,R-DPEN), RuHCl(R,R-DPPACH)(R,R-CYDN) and RuHCl(R,R-DPPACH)(R,R-DPEN) were prepared as described by Abdur-Rashid et al. (Organometallics, 2001, 21, 1047). NMR spectra were recorded on either a Varian Gemini 300 MHz spectrometer (300 MHz for ¹H, 75 MHz for ¹³C and 121.5 for ³¹P) or a Varian Unity 400 MHz spectrometer (400 MHz for ¹H and 100 MHz for ¹³C). All ³¹P spectra were recorded with proton decoupling and ³¹P chemical shifts were measured relative to 85% H₃PO₄ as an external reference. ¹H and ¹³C chemical shifts were measured relative to partially deuterated solvent peaks but are reported relative to tetramethylsilane. Infrared spectra were obtained on a Nicolet 550 Magna-IR spectrometer.

Example 1: Preparation of the ligand R,R-DCYPPACH and complexes

[0053] R,R-1,2-Bis(dicyclohexylphosphinamino)cyclohexane (R,R-DCYPPACH): A solution of chlorodicyclohexylphosphine (4.07 g, 17.5 mmol) in toluene (20 ml) was added dropwise to a solution of R,R-1,2-cyclohexyldiamine (1.0 g, 8.75 mmol) and triethylamine (2.0 g, 19.4 mmol) in toluene (20 ml) and the resulting suspension stirred for 6 hours at room temperature. It was then evaporated to dryness, the solids washed with ethanol (2x10 ml) (in order to remove triethylammonium chloride) and hexanes (3 x 5 ml) and dried under vacuum. Yield = 3.86 g, 87%. ¹H NMR: 0.95-2.38 ppm (m); ^3IP{¹H} NMR: 51.3 ppm (s).

[0054] RuHCl(R,R-DCYPPACH)(PPh₃): Tetrahydrofuran (10 ml) was added to RuHCl(PPh₃)₃ (1.50 g, 1.63 mmol) and R,R-DCYPPACH (900 mg, 1.77 mmol) and the mixture refluxed for 4 hours under argon. The mixture was filtered and the brick-red solution used as a stock solution, since the product is an oil at room temperature. ¹H NMR: -16.70 ppm (dt, 1H, RuH, ²J_HP = 35.1, 22.2 Hz), 0.52-3.58 ppm (m, 56H), 7.02-7.39 ppm (m, 15H). ³¹P(¹H}: 38.21 ppm (br d, ²J_PP = 252 Hz), 110.1 ppm (br d, ²J_PP = 252 Hz), 142 ppm (br s).

[0055] RuHCl(R,R-DCYPPACH)(R,R-CYDN): Tetrahydrofuran (2 ml) was added to a mixture of RuHCl(R,R-DCYPPACH)(PPh₃) (300 mg, 0.34 mmol) and R,R-cyclohexyldiamine (40mg, 0.35 mmol) and the resulting solution stirred for 30 minutes under nitrogen. It was then filtered and the solution used as a stock for the complex, which is a pale yellow oil at room temperature. ¹H NMR: -19.1 ppm (dd, 1H, RuH, ²J_HP = 28.8 Hz, ²J_PP = 42.7 Hz), 0.05-3.54 ppm (m, 56H). ³¹P{¹H}_: 128.5 ppm (d), 108.2 ppm (d), ²J_PP = 42.7 Hz.

Example 2: Preparation of Imines

[0056] All imines were prepared by refluxing stoichiometric amounts of the appropriate ketone and amine in toluene or THF over 4 A molecular sieves until there is no further change in the composition of the mixture with time. The excess ketone and amine are removed under vacuum, and the resulting imine purified by distillation.

Structure of Ligands

[0057] 

R-BINAP	R,R-DPPACH
R,R-CYDN	R,R-DCYPPACH
R,R-DPEN

Exampe 3: Catalytic hydrogenation

[0058] The required substrate was added to a mixture of the catalyst precursor and KOⁱPr or KO^tBu in a 250 ml Schlenk flask (benzene or THF was added to dissolve solid imines), which was then cooled to liquid nitrogen temperature. The flask was evacuated under vacuum, filled with H₂ gas, closed and allowed to gradually warm to room temperature. The mixture was stirred vigorously until either hydrogenation is complete or no further change in the composition is observed (NMR). A typical procedure for the hydrogenation of N-(1,5-dimethyl-4-hexenylidene)aniline is illustrated below: A solution of N-(1,5-dimethyl-4-hexenylidene)aniline (2.0 g) in benzene (2 ml) was added under a flow of hydrogen gas to a mixture of RuHCl(R,R-BINAP)(R,R-CYDN) (5 mg) and KOⁱPr (5 mg) in a Schlenk flask. The flask was then cooled to liquid nitrogen temperature, filled with H₂ gas, closed and allowed to gradually warm to room temperature. The mixture was vigorously stirred for 24 hours. A ¹H NMR spectrum of the reaction mixture indicated complete conversion of the imine to the amine. Hexane (10 ml) was added to the mixture, which was then eluted (hexane) through a short column of silica gel in order to remove the spent catalyst and KOⁱPr. Evaporation of the hexane under reduced pressure resulted in spectroscopically pure N-(1,5-dimethyl-4-hexenyl)aniline, as verified by ¹H and ¹³C NMR.

[0059] Proof of principle catalytic hydrogenation results using the series of ruthenium monohydride complexes are summarized below.

(a) Hydrogenation of N-(1-cyclopropylethylidene)aniline

[0060] 

Catalyst Precursor	S : C	Conversion (%)	Time (hr)
RuHCl(R-BINAP)(R,R-CYDN)	1700	100	< 48
RuHCl(R-BINAP)(R,R-DPEN)	1700	100	<48

(b) Hydrogenation N-(1-cyclobutylethylidene)aniline

[0061] 

Catalyst Precursor	S : C	Conversion (%)	Time (hr)
RuHCl(R-BINAP)(R,R-DPEN)	1600	100	< 30

(c) Hydrogenation of N-(1-aza-bicyclo[2.2.2]oct-3-ylidene)anitine

[0062] 

Catalyst Precursor	S : C	Conversion (%)	Time (hr)
RuHCl(R-BINAP)(R,R-CYDN)	200	100a	< 12
RuHCl(R-BINAP)(R,R-DPEN)	500	100b	< 12
RuHCl(R,R-DPPACH)(R,R-CYDN)	200	100	< 12
RuHCl(R,R-DPPACH)(R,R-DPEN)	200	100	< 12
RuHCl(R,R-DCYPPACH)(R,R-CYDN)	200	0	12

a Rotation (αD) = 24.7° (c =1.0, CH2Cl2) b Rotation (αD) = 24.2° (c = 1.0, CH2Cl2)

(d) Hydrogenation of N-(1,2-dimethyl-propylidene)aniline

[0063] 

Catalyst Precursor	S : C	Conversion (%)	Time (hr)
RuHCl(R-BINAP)(R,R-CYDN)	600	92	60
RuHCl(R-BINAP)(R,R-DPEN)	600	95	72

(e) Hydrogenation of N-(1,5-dimethyl-4-hexenylidene)aniline

[0064] 

Catalyst Precursor	S : C	Conversion (%)	Time (hr)
RuHCl(R-BINAP)(R,R-CYDN)	1300	100c	48
RuHCl(R-BINAP)(R,R-DPEN)	1300	100d	60

c Rotation (αD) = 4.6° (c = 1.0, CH2Cl2) d Rotation (αD) = 4.2° (c = 1.0, CH2Cl2)

(f) Hydrogenation of N-(1,2-dimethyl-3-phenyl-allylidene)aniline

[0065] 

Catalyst Precursor	S : C	Conv. (IV, V %)	Time (hr) e.e.
RuHCl(binap)(cydn)	200	17,83	24
RuHCl(binap)(dpen)	200	22, 78	24
RuHCl(dppach)(cydn)	500	34,66	4
RuHCl(dppach)(dpen)	500	75,25	4

(g) Hydrogenation of N-(1,2,2-trimethyl-propylidene)aniline

[0066] 

Catalyst Precursor	S : C	Conversion (%)	Time (hr)
RuHCl(R-BINAP)(R,R-DPEN)	250	5	24

(h) Hydrogenation of N-(1,2-dimethyl-3-(2-chlorophenyl)-allylidene)aniline

[0067] 

Catalyst Precursor	S : C	Conv. (IV, V %)	Time (hr) e.e.
RuHCl(binap)(cydn)	200	21, 79	24
RuHCl(binap)(dpen)	200	24, 76	24
RuHCl(dppach)(cydn)	500	38,62	4
RuHCl(dppach)(dpen)	500	78,22	4

Claims

1. A process for the hydrogenation and/or asymmetric hydrogenation of dialkyl, alkylalkenyl or dialkenyl imines of formula II to amines of formula III:

wherein

R¹ and R² are independently selected from the group consisting of optionally substituted cyclic, linear and branched alkyl and alkenyl and wherein R¹ and R² may also be linked together, or with R³, to form one or more rings; and

R³ is selected from the group consisting of hydrogen, hydroxy, optionally substituted C₁ to C₈ cyclic, linear and branched alkyl and alkenyl, and optionally substituted aryl; said process comprising the steps of reacting imines of formula II in the presence of H₂ and a catalytic system comprising a base and a ruthenium complex containing (1) a diamine and (2) a diphosphine ligand or monodentate phosphine ligands.

2. The process according to claim 1, which is for preparing enantiomerically enriched chiral dialkyl, alkylalkenyl or dialkenyl amines of formula III, or the opposite enantiomer thereof.

3. The process according to any one of claims 1-2, wherein said ruthenium complex has the general formula RuXY(PR₃)₂(NH₂-Z-NH₂) (IV) or RuXY(R₂P-Q-PR₂)(NH₂-Z-NH₂) (V), wherein Z and Q represent chiral or achiral linkers, the ancilliary ligands, PR₃ and R₂P-Q-PR₂, represent chrial or achrial monodentate and bidentate phosphines, respectively and the ligands X and Y represent any anionic ligand.

4. The process according to claim 3, wherein the ligand PR₃ (VI):



        PR₃     (VI)

represents a chiral or achiral monodentate phosphine ligand wherein each R, taken separately, is independently selected from the group consisting of optionally substituted linear and branched alkyl and alkenyl containing 1 to 8 carbon atoms, optionally substituted cycloalkyl, optionally substituted aryl, or OR and NR₂, wherein R is as previously defined; or two R groups bonded to the same P atom are bonded together to form an optionally substituted saturated or aromatic ring having 5 to 8 atoms including the phosphorous atom to which said R groups are bonded.

5. The process according to claim 3, wherein the ligand R₂P-Q-PR₂ (VII):



        R₂P-Q-PR₂     (VII)

represents a chiral or achiral bidentate ligand wherein each R, taken separately, is independently selected from the group consisting of optionally substituted linear and branched alkyl and alkenyl containing 1 to 8 carbon atoms, optionally substituted cycloalkyl, optionally substituted aryl, or OR and NR₂, wherein R is as previously defined; or two R groups bonded to the same P atom are bonded together to form an optionally substituted saturated or aromatic ring having 5 to 8 atoms including the phosphorous atom to which said R groups are bonded; Q is selected from the group consisting of optionally substituted linear and cyclic C₂-C₇ alkylene, optionally substituted metallocenediyl and optionally substituted C₆-C₂₂ arylene.

6. The process according to claim 5, wherein the ligand R₂P-Q-PR₂ (VII) is chiral and includes atropisomeric bis-tertiary phosphines, in which the two phosphorus atoms are linked by a biaryl backbone.

7. The process according to claim 6, wherein the ligand R₂P-Q-PR₂ (VII) is selected from the group consisting of BINAP, BIPHEP and BIPHEMP.

8. The process according to claim 3, wherein the bidentate phosphine is a chiral or achiral ligand of the formula R₂P-NR'-Z-NR'-PR₂ (VIII):



        R₂P-NR'-Z-NR'-PR₂     (VIII)

wherein each R, taken separately, is independently selected from the group consisting of optionally substituted linear and branched alkyl and alkenyl containing 1 to 8 carbon atoms, optionally substituted cycloalkyl, optionally substituted aryl, or OR and NR₂, wherein R is as previously defined; or two R groups bonded to the same P atom are bonded together to form an optionally substituted saturated or aromatic ring having 5 to 8 atoms including the phosphorous atom to which said R groups are bonded; each R', taken separately, is independently selected from the group consisting of hydrogen, optionally substituted linear and branched alkyl or alkenyl containing 1 to 8 carbon atoms, optionally substituted cycloalkyl and optionally substituted aryl; and Z is selected from the group consisting of optionally substituted linear and cyclic C₂-C₇ alkylene, optionally substituted metallocenediyl and optionally substituted C₆-C₂₂ arylene.

9. The process according to claim 8, wherein the ligand R₂P-NR'-Z NR'-PR₂ (VIII) is selected from the group consisting of R,R-DPPACH and R, R-DCYPPACH.

10. The process according to any one of claims 1-8, wherein the diamine ligand has the formula NH₂-Z-NH₂ (IX):



        H₂N-Z-NH₂     (IX)

wherein Z is selected from the group consisting of optionally substituted linear and cyclic C₂-C₇ alkylene, optionally substituted metallocenediyl and optionally substituted C₆-C₂₂ arylene.

11. The process according to claim 10, wherein the diamine ligand is chiral and includes (1) compounds in which at least one of the amine-bearing centers is stereogenic, (2) compounds in which both of the amine-bearing centers are stereogenic and (3) atropisomeric bis-tertiary diamines, in which the two nitrogen atoms are linked by a biaryl backbone.

12. The process according to claim 10, wherein the diamine ligand NH₂-Z-NH₂ (IX) is selected from the group consisting of R,R-CYDN and R,R-DPEN.

13. The process according to any one of claims 1-2, wherein the diamine is a bidentate ligand of the formula D-Z-NHR⁴ (X), wherein Z is selected from the group consisting of optionally substituted linear and cyclic C₂-C₇ alkylene, optionally substituted metallocenediyl and optionally substituted C₆-C₂₂ arylene; D is an amido group donor; and R⁴ is selected from the group consisting of hydrogen, optionally substituted linear and branched alkyl and alkenyl containing 1 to 8 carbon atoms, optionally substituted cycloalkyl and optionally substituted aryl.

14. The process according to claim 13 wherein D is NR⁵, wherein R⁵ is selected from the group consisting of S(O)₂R⁶, P(O)(R⁶)₂, C(O)R⁶, C(O)N(R⁶)₂ and C(S)N(R⁶)₂ wherein each R⁶, taken separately, is independently selected from the group consisting of hydrogen, optionally substituted linear and branched alkyl and alkenyl containing 1 to 8 carbon atoms, optionally substituted cycloalkyl and optionally substituted aryl.

15. The process according to claim 13, wherein the diamine is chiral and includes (1) compounds in which the amine-bearing center is stereogenic, and (2) compounds in which both amido group donor (D)-bearing and amine-bearing centers are stereogenic.

16. The process according to any one of claims 3-15, wherein the ligands X and Y are selected from the group consisting of Cl, Br, I, H, hydroxy, alkoxy or acyloxy.

17. The process according to any one of claims 1 to 16, wherein the base is an alcoholate or an hydroxide salt selected from the group consisting of the compounds of formula (R⁷O)₂M' and R⁷OM", wherein M' is an alkaline-earth metal, M" is an alkaline metal and R⁷ stands for hydrogen or C₁ to C₆ linear or branched alkyl.

18. The process according to any one of claims 1 to 16, wherein the base is an organic non-coordinating base.

19. The process according to claim 18, wherein the base is selected from the group consisting of DBU, NR₃ and phosphazene.

20. The process according to any one of claims 1 to 19, wherein the hydrogenation is carried out in the absence of a solvent.

21. The process according to any one of claims 1 to 20, wherein the hydrogenation reaction is carried out in the presence of a solvent.

22. The process according to claim 21, wherein the solvent is selected from the group consisting of benzene, toluene, xylene, hexane, cyclohexane, tetrahydrofuran, primary and secondary alcohols, and mixtures thereof.

Ansprüche

1. Verfahren zur Hydrierung und/oder asymmetrischen Hydrierung von Dialkyl-, Alkylalkenyl- oder Dialkenyliminen der Formel II zu Aminen der Formel III:

wobei R¹ und R² unabhängig aus der Gruppe ausgewählt sind bestehend aus wahlweise substituiertem cyclischem, linearem und verzweigtem Alkyl und Alkenyl und wobei R¹ und R² ebenfalls miteinander oder mit R³ zur Bildung eines oder mehrerer Ringe verknüpft sein können; und

R³ aus der Gruppe ausgewählt ist bestehend aus Wasserstoff, Hydroxy, wahlweise substituiertem cyclischem, linearem und verzweigtem C₁- bis C₈-Alkyl und -Alkenyl und wahlweise substituiertem Aryl; wobei das Verfahren die Schritte des Reagierens von Iminen der Formel II in Anwesenheit von H₂ und einem katalytischen System umfasst, das eine Base und einen Rutheniumkomplex umfasst, der (1) einen Diamin- und (2) einen Diphosphinliganden oder einzählige Phosphinliganden enthält.

2. Verfahren nach Anspruch 1, das der Herstellung von enantiomer angereicherten chiralen Dialkyl-, Alkylalkenyl- oder Dialkenylaminen der Formel III oder des entgegengesetzten Enantiomers davon dient.

3. Verfahren nach einem der Ansprüche 1-2, wobei der Rutheniumkomplex die allgemeine Formel RuXY(PR₃)₂(NH₂-Z-NH₂) (IV) oder RuXY(R₂P-Q-PR₂)(NH₂-Z-NH₂) (V) aufweist, wobei Z und Q chirale oder achirale Verknüpfer darstellen, die zusätzlichen Liganden PR₃ und R₂P-Q-PR₂ jeweils chirale oder achirale einzählige und zweizählige Phosphine darstellen und die Liganden X und Y irgendeinen anionischen Liganden darstellen.

4. Verfahren nach Anspruch 3, wobei der Ligand PR₃ (VI):



        PR₃     (VI)

einen chiralen oder achiralen einzähligen Phosphinliganden darstellt, wobei jedes R einzeln genommen unabhängig ausgewählt ist aus der Gruppe bestehend aus wahlweise substituiertem linearem und verzweigtem Alkyl und Alkenyl, das 1 bis 8 Kohlenstoffatome enthält, wahlweise substituiertem Cycloalkyl, wahlweise substituiertem Aryl oder OR und NR₂, wobei R wie oben definiert ist; oder zwei R-Gruppen, die an dasselbe P-Atom gebunden sind, zur Bildung eines wahlweise substituierten gesättigten oder aromatischen Rings zusammengebunden sind, der 5 bis 8 Atome, einschließlich des Phosphoratoms, an das die R-Gruppen gebunden sind, aufweist.

5. Verfahren nach Anspruch 3, wobei der Ligand R₂P-Q-PR₂ (VII):



        R₂P-Q-PR₂     (VII)

einen chiralen oder achiralen zweizähligen Liganden darstellt, wobei jedes R einzeln genommen unabhängig ausgewählt ist aus der Gruppe bestehend aus wahlweise substituiertem linearem und verzweigtem Alkyl und Alkenyl, das 1 bis 8 Kohlenstoffatome enthält, wahlweise substituiertem Cycloalkyl, wahlweise substituiertem Aryl oder OR und NR₂, wobei R wie oben definiert ist; oder zwei R-Gruppen, die an dasselbe P-Atom gebunden sind, zur Bildung eines wahlweise substituierten gesättigten oder aromatischen Rings zusammengebunden sind, der 5 bis 8 Atome, einschließlich des Phosphoratoms, an das die R-Gruppen gebunden sind, aufweist; Q aus der Gruppe ausgewählt ist bestehend aus wahlweise substituiertem linearem und cyclischem C₂-C₇-Alkylen, wahlweise substituiertem Metallocendiyl und wahlweise substituiertem C₆-C₂₂-Arylen.

6. Verfahren nach Anspruch 5, wobei der Ligand R₂P-Q-PR₂ (VII) chiral ist und atropisomere bis-tertiäre Phosphine umfasst, wobei die beiden Phosphoratome durch eine Biarylrückgratkette verknüpft sind.

7. Verfahren nach Anspruch 6, wobei der Ligand R₂P-Q-PR₂ (VII) aus der Gruppe ausgewählt ist bestehend aus BINAP, BIPHEP und BIPHEMP.

8. Verfahren nach Anspruch 3, wobei das zweizählige Phosphin ein chiraler oder achiraler Ligand der Formel R₂P-NR'-Z-NR'-PR₂ (VIII) ist:



        R₂P-NR'-Z-NR'-PR₂     (VIII)

wobei jedes R einzeln genommen unabhängig ausgewählt ist aus der Gruppe bestehend aus wahlweise substituiertem linearem und verzweigtem Alkyl und Alkenyl, das 1 bis 8 Kohlenstoffatome enthält, wahlweise substituiertem Cycloalkyl, wahlweise substituiertem Aryl oder OR und NR₂, wobei R wie oben definiert ist; oder zwei R-Gruppen, die an dasselbe P-Atom gebunden sind, zur Bildung eines wahlweise substituierten gesättigten oder aromatischen Rings zusammengebunden sind, der 5 bis 8 Atome, einschließlich des Phosphoratoms, an das die R-Gruppen gebunden sind, aufweist; jedes R' einzeln genommen unabhängig aus der Gruppe ausgewählt ist bestehend aus Wasserstoff, wahlweise substituiertem linearem und verzweigtem Alkyl oder Alkenyl, das 1 bis 8 Kohlenstoffatome enthält, wahlweise substituiertem Cycloalkyl und wahlweise substituiertem Aryl; und Z aus der Gruppe ausgewählt ist bestehend aus wahlweise substituiertem linearem und cyclischem C₂-C₇-Alkylen, wahlweise substituiertem Metallocendiyl und wahlweise substituiertem C₆-C₂₂-Arylen.

9. Verfahren nach Anspruch 8, wobei der Ligand R₂P-NR'-Z-NR'-PR₂ (VIII) aus der Gruppe ausgewählt ist bestehend aus R,R-DPPACH und R, R-DCYPPACH.

10. Verfahren nach einem der Ansprüche 1-8, wobei der Diaminligand die Formel NH₂-Z-NH₂ (IX) aufweist:



        H₂N-Z-NH₂     (IX)

wobei Z aus der Gruppe ausgewählt ist bestehend aus wahlweise substituiertem linearem und cyclischem C₂-C₇-Alkylen, wahlweise substituiertem Metallocendiyl und wahlweise substituiertem C₆-C₂₂-Arylen.

11. Verfahren nach Anspruch 10, wobei der Diaminligand chiral ist und (1) Verbindungen, in denen mindestens einer der amintragenden Zentren stereogen ist, (2) Verbindungen, in denen beide der amintragenden Zentren stereogen sind und (3) atropisomere bis-tertiäre Diamine umfasst, in denen die beiden Stickstoffatome durch eine Biarylrückgratkette verknüpft sind.

12. Verfahren nach Anspruch 10, wobei der Diaminligand NH₂-Z-NH₂ (IX) aus der Gruppe ausgewählt ist bestehend aus R,R-CYDN und R,R-DPEN.

13. Verfahren nach einem der Ansprüche 1-2, wobei das Diamin ein zweizähliger Ligand der Formel D-Z-NHR⁴ (X) ist, wobei Z aus der Gruppe ausgewählt ist bestehend aus wahlweise substituiertem linearem und cyclischem C₂-C₇-Alkylen, wahlweise substituiertem Metallocendiyl und wahlweise substituiertem C₆-C₂₂-Arylen; D ein Amidogruppendonator ist; und R⁴ aus der Gruppe ausgewählt ist bestehend aus Wasserstoff, wahlweise substituiertem linearem und verzweigtem Alkyl und Alkenyl, das 1 bis 8 Kohlenstoffatome enthält, wahlweise substituiertem Cycloalkyl und wahlweise substituiertem Aryl.

14. Verfahren nach Anspruch 13, wobei D NR⁵ ist, wobei R⁵ aus der Gruppe ausgewählt ist bestehend aus S(O)₂R⁶, P(O)(R⁶)₂, C(O)R⁶, C(O)N(R⁶)₂ und C(S)N(R⁶)₂, wobei R⁶ einzeln genommen unabhängig aus der Gruppe ausgewählt ist bestehend aus Wasserstoff, wahlweise substituiertem linearem und verzweigtem Alkyl und Alkenyl, das 1 bis 8 Kohlenstoffatome enthält, wahlweise substituiertem Cycloalkyl und wahlweise substituiertem Aryl.

15. Verfahren nach Anspruch 13, wobei das Diamin chiral ist und (1) Verbindungen, in denen der amintragende Zenter stereogen ist und (2) Verbindungen umfasst, in denen beide Amidogruppendonatoren (D) tragende und amintragende Zentren stereogen sind.

16. Verfahren nach einem der Ansprüche 3-15, wobei die Liganden X und Y aus der Gruppe ausgewählt sind bestehend aus Cl, Br, I, H, Hydroxy, Alkoxy oder Acyloxy.

17. Verfahren nach einem der Ansprüche 1 bis 16, wobei die Base ein Alkoholat oder ein Hydroxidsalz ist ausgewählt aus der Gruppe bestehend aus den Verbindungen der Formel (R⁷O)₂M' und R⁷OM", wobei M' ein Erdalkalimetall, M" ein Alkalimetall ist und R⁷ für Wasserstoffoder lineares oder verzweigtes C₁-bis C₆-Alkyl steht.

18. Verfahren nach einem der Ansprüche 1 bis 16, wobei die Base eine organische nichtkoordinierende Base ist.

19. Verfahren nach Anspruch 18, wobei die Base aus der Gruppe ausgewählt ist bestehend aus DBU, NR₃ und Phosphazen.

20. Verfahren nach einem der Ansprüche 1 bis 19, wobei die Hydrierung in Abwesenheit eines Lösungsmittels durchgeführt wird.

21. Verfahren nach einem der Ansprüche 1 bis 20, wobei die Hydrierungsreaktion in Gegenwart eines Lösungsmittels durchgeführt wird.

22. Verfahren nach Anspruch 21, wobei das Lösungsmittel aus der Gruppe ausgewählt ist bestehend aus Benzol, Toluol, Xylol, Hexan, Cyclohexan, Tetrahydrofuran, primären und sekundären Alkoholen und Mischungen davon.

Revendications

1. Procédé d'hydrogénation et/ou d'hydrogénation asymétrique de dialkyl-, d'alkylalcényl- ou de dialcényl-imines de formule II en amines de formule III:

où

R¹ et R² sont indépendamment choisis dans le groupe constitué des groupes alkyle et alcényle cycliques, linéaires et ramifiés, éventuellement substitués, et R¹ et R² peuvent également être liés ensemble, ou avec R³, pour former un ou plusieurs cycles; et

R³ est choisi dans le groupe constitué d'un hydrogène, d'un groupe hydroxy, des groupes alkyle et alcényle cycliques, linéaires et ramifiés, éventuellement substitués, en C₁ à C₈, et des groupes aryle éventuellement substitués;

ledit procédé comprenant les étapes consistant à faire réagir des imines de formule II en présence de H₂ et d'un système catalytique comprenant une base et un complexe de ruthénium contenant (1) une diamine et (2) un ligand diphosphine ou des ligands phosphines monodentés.

2. Procédé selon la revendication 1, qui est destiné à la préparation de dialkyl-, d'alkylalcényl- ou de dialcényl-amines chirales de formule III énantiomériquement enrichies, ou de leur énantiomère opposé.

3. Procédé selon l'une quelconque des revendications 1-2, dans lequel ledit complexe de ruthénium a comme formule générale RuXY(PR₃)₂(NH₂-Z-NH₂) (IV) ou RuXY(R₂P-Q-PR₂)(NH₂-Z-NH₂) (V), où Z et Q représentent des lieurs chiraux ou achiraux, les ligands auxiliaires, PR₃ et R₂P-Q-PR₂, représentent respectivement des phosphines monodentées et bidentées chirales ou achirales, et les ligands X et Y représentent tout ligand anionique.

4. Procédé selon la revendication 3, dans lequel le ligand PR₃ (VI):

représente un ligand phosphine monodenté chiral ou achiral dans lequel chaque R, pris séparément, est indépendamment choisi dans le groupe constitué des groupes alkyle et alcényle linéaires et ramifiés, éventuellement substitués, contenant 1 à 8 atomes de carbone, des groupes cycloalkyle éventuellement substitués, des groupes aryle éventuellement substitués, ou OR et NR₂, où R est tel que défini précédemment; ou deux groupes R liés au même atome de P sont liés ensemble pour former un cycle saturé ou aromatique éventuellement substitué ayant 5 à 8 atomes y compris l'atome de phosphore auquel lesdits groupes R sont liés.

5. Procédé selon la revendication 3, dans lequel le ligand R₂P-Q-PR₂ (VII):



        R₂P-Q-PR₂     (VII)

représente un ligand bidenté chiral ou achiral dans lequel chaque R, pris séparément, est indépendamment choisi dans le groupe constitué des groupes alkyle et alcényle linéaires et ramifiés, éventuellement substitués, contenant 1 à 8 atomes de carbone, des groupes cycloalkyle éventuellement substitués, des groupes aryle éventuellement substitués, ou OR et NR₂, où R est tel que défini précédemment; ou deux groupes R liés au même atome de P sont liés ensemble pour former un cycle saturé ou aromatique éventuellement substitué ayant 5 à 8 atomes y compris l'atome de phosphore auquel lesdits groupes R sont liés; Q est choisi dans le groupe constitué des groupes alkylène en C₂-C₇ linéaires et cycliques éventuellement substitués, des groupes métallocènediyle éventuellement substitués et des groupes arylène en C₆-C₂₂ éventuellement substitués.

6. Procédé selon la revendication 5, dans lequel le ligand R₂P-Q-PR₂ (VII) est chiral et inclut des bis-phosphines tertiaires atropisomériques, dans lesquelles les deux atomes de phosphore sont reliés par un squelette biaryle.

7. Procédé selon la revendication 6, dans lequel le ligand R₂P-Q-PR₂ (VII) est choisi dans le groupe constitué de BINAP, de BIPHEP et de BIPHEMP.

8. Procédé selon la revendication 3, dans lequel la phosphine bidentée est un ligand chiral ou achiral de formule R₂P-NR'-Z-NR'-PR₂ (VIII):



        R₂P-NR'-Z-NR'-PR₂     (VIII)

où chaque R, pris séparément, est indépendamment choisi dans le groupe constitué des groupes alkyle et alcényle linéaires et ramifiés, éventuellement substitués, contenant 1 à 8 atomes de carbone, des groupes cycloalkyle éventuellement substitués, des groupes aryle éventuellement substitués, ou OR et NR₂, où R est tel que défini précédemment; ou deux groupes R liés au même atome de P sont liés ensemble pour former un cycle saturé ou aromatique éventuellement substitué ayant 5 à 8 atomes y compris l'atome de phosphore auquel lesdits groupes R sont liés; chaque R', pris séparément, est indépendamment choisi dans le groupe constitué d'un hydrogène, des groupes alkyle ou alcényle linéaires et ramifiés, éventuellement substitués, contenant 1 à 8 atomes de carbone, des groupes cycloalkyle éventuellement substitués et des groupes aryle éventuellement substitués; et Z est choisi dans le groupe constitué des groupes alkylène en C₂-C₇ linéaires et cycliques éventuellement substitués, des groupes métallocènediyle éventuellement substitués et des groupes arylène en C₆-C₂₂ éventuellement substitués.

9. Procédé selon la revendication 8, dans lequel le ligand R₂P-NR'-Z-NR'-PR₂ (VIII) est choisi dans le groupe constitué de R,R-DPPACH et de R,R-DCYPPACH.

10. Procédé selon l'une quelconque des revendications 1-8, dans lequel le ligand diamine a comme formule NH₂-Z-NH₂ (IX):



        H₂N-Z-NH₂     (IX)

dans laquelle Z est choisi dans le groupe constitué des groupes alkylène en C₂-C₇ linéaires et cycliques éventuellement substitués, des groupes métallocènediyle éventuellement substitués et des groupes arylène en C₆-C₂₂ éventuellement substitués.

11. Procédé selon la revendication 10, dans lequel le ligand diamine est chiral et inclut (1) les composés dans lesquels au moins un des centres porteurs d'une amine est stéréogène, (2) les composés dans lesquels chacun des deux centres porteurs d'une amine sont stéréogènes et (3) les bis-diamines tertiaires atropisomériques, dans lesquelles les deux atomes d'azote sont reliés par un squelette biaryle.

12. Procédé selon la revendication 10, dans lequel le ligand diamine NH₂-Z-NH₂ (IX) est choisi dans le groupe constitué de R,R-CYDN et de R,R-DPEN.

13. Procédé selon l'une quelconque des revendications 1-2, dans lequel la diamine est un ligand bidenté de formule D-Z-NHR⁴ (X), où Z est choisi dans le groupe constitué des groupes alkylène en C₂-C₇ linéaires et cycliques éventuellement substitués, des groupes métallocènediyle éventuellement substitués et des groupes arylène en C₆-C₂₂ éventuellement substitués; D est un donneur de groupe amido; et R⁴ est choisi dans le groupe constitué d'un hydrogène, des groupes alkyle et alcényle linéaires et ramifiés, éventuellement substitués, contenant 1 à 8 atomes de carbone, des groupes cycloalkyle éventuellement substitués et des groupes aryle éventuellement substitués.

14. Procédé selon la revendication 13 dans lequel D représente NR⁵, où R⁵ est choisi dans le groupe constitué de S(O)₂R⁶, P(O)(R⁶)₂, C(O)R⁶, C(O)N(R⁶)₂ et C(S)N(R⁶)₂ où chaque R⁶, pris séparément, est indépendamment choisi dans le groupe constitué d'un hydrogène, des groupes alkyle et alcényle linéaires et ramifiés, éventuellement substitués, contenant 1 à 8 atomes de carbone, des groupes cycloalkyle éventuellement substitués et des groupes aryle éventuellement substitués.

15. Procédé selon la revendication 13, dans lequel la diamine est chirale et inclut (1) les composés dans lesquels le centre porteur d'une amine est stéréogène, et (2) les composés dans lesquels à la fois le centre porteur d'une amine et le centre porteur du donneur de groupe amido (D) sont stéréogènes.

16. Procédé selon l'une quelconque des revendications 3-15, dans lequel les ligands X et Y sont choisis dans le groupe constitué des atomes de Cl, Br, I, H, et des groupes hydroxy, alcoxy ou acyloxy.

17. Procédé selon l'une quelconque des revendications 1 à 16, dans lequel la base est un sel alcoolate ou hydroxyde choisi dans le groupe constitué des composés de formule (R⁷O)₂M' et R⁷OM", où M' est un métal alcalino-terreux, M" est un métal alcalin et R⁷ représente un hydrogène ou un groupe alkyle linéaire ou ramifié en C₁ à C₆.

18. Procédé selon l'une quelconque des revendications 1 à 16, dans lequel la base est une base organique non coordinante.

19. Procédé selon la revendication 18, dans lequel la base est choisie dans le groupe constitué de DBU, de NR₃ et du phosphazène.

20. Procédé selon l'une quelconque des revendications 1 à 19, dans lequel l'hydrogénation est effectuée en l'absence de solvant.

21. Procédé selon l'une quelconque des revendications 1 à 20, dans lequel la réaction d'hydrogénation est effectuée en présence d'un solvant.

22. Procédé selon la revendication 21, dans lequel le solvant est choisi dans le groupe constitué du benzène, du toluène, du xylène, de l'hexane, du cyclohexane, du tétrahydrofurane, des alcools primaires et secondaires, et de leurs mélanges.