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(11)

EP 1 503 980 A2

(12)

(88) Date of publication A3: 30.09.2004 (43) Date of publication: 09.02.2005 Bulletin 2005/06 (21) Application number: 03743271.3 (22) Date of filing: 27.02.2003

(51) International Patent Classification (IPC)7: C07C 233/78, C07D 295/20, C07D 307/20, A61K 31/166, A61K 31/132, A61K 31/33, A61P 25/28, C07C 271/16, C07C 271/20, C07C 217/58, C07C 247/10, C07C 247/12, C07C 255/57, C07C 311/16, C07D 295/22 (86) International application number: PCT/US2003/007287 (87) International publication number: WO 2003/072535 (04.09.2003 Gazette 2003/36)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 27.02.2002 US 359953 P (71) Applicants: Elan Pharmaceuticals, Inc. South San Francisco, CA 94080 (US) Pharmacia & Upjohn Kalamazoo, MI 49007 (US)

(72) Inventors: VARGHESE, John San Francisco, CA 94122 (US) JAGODZINSKA, Barbara Redwood City, CA 95061 (US) MAILLARD, Michel Redwood Shores, CA 94065 (US) BECK, James, P. Kalamazoo, MI 49009 (US) TENBRINK, Ruth, E. Kalamazoo, MI 49004 (US) GETMAN, Daniel Chesterfield, MO 63017 (US) (74) Representative: Nargolwalla, Cyra et al Cabinet Plasseraud65/67 rue de la Victoire 75440 Paris Cedex 09 75440 Paris Cedex 09 (FR)