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<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTRBGCZEEHU..SK....................................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>BDM Ver 0.1.63 (23 May 2017) -  2999001/0</B007EP><B078EP><date>20110104</date></B078EP><B090EP><B0900EP limitation-sequence="1"><B091EP><B0911EP><date>20170927</date></B0911EP><B0912EP>02</B0912EP><B0913EP>01</B0913EP><B0914EP><date>20170927</date></B0914EP></B091EP><B093EP><B0931EP><date>20171106</date></B0931EP><B0932EP><date>20171107</date></B0932EP><B0933EP><date>20171107</date></B0933EP></B093EP></B0900EP></B090EP></eptags></B000><B100><B110>1504035</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20180228</date></B140><B150><B151>W1</B151><B153>74</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>03718974.3</B210><B220><date>20030502</date></B220><B240><B241><date>20041201</date></B241><B242><date>20060116</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>0210121</B310><B320><date>20020502</date></B320><B330><ctry>GB</ctry></B330></B300><B400><B405><date>20180228</date><bnum>201809</bnum></B405><B430><date>20050209</date><bnum>200506</bnum></B430><B450><date>20100331</date><bnum>201013</bnum></B450><B452EP><date>20091009</date></B452EP><B453EP><B4530EP sequence="1" limitation-sequence="1"><kind>B3</kind><date>20171220</date><bnum>201751</bnum></B4530EP></B453EP><B480><date>20180228</date><bnum>201809</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>C07K  16/28        20060101AFI20031118BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>C12N  15/13        20060101ALI20031118BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>C12N  15/85        20060101ALI20031118BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>C12N   5/10        20060101ALI20031118BHEP        </text></classification-ipcr><classification-ipcr sequence="5"><text>A61K  39/395       20060101ALI20031118BHEP        </text></classification-ipcr><classification-ipcr sequence="6"><text>A61K  31/7088      20060101ALI20031118BHEP        </text></classification-ipcr><classification-ipcr sequence="7"><text>A61P  35/00        20060101ALI20031118BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>ANTIKÖRPER GEGEN HUMANES CD22 UND DEREN THERAPEUTISCHE UND DIAGNOSTISCHE VERWENDUNGEN</B542><B541>en</B541><B542>ANTIBODIES SPECIFIC FOR HUMAN CD22 AND THEIR THERAPEUTIC AND DIAGNOSTIC USES</B542><B541>fr</B541><B542>ANTICORPS SPECIFIQUES A L' HUMAIN CD22 ET LEURS UTILISATION THERAPEUTIQUES ET DIAGNOSTIQUES</B542></B540><B560><B561><text>WO-A-00/31141</text></B561><B561><text>WO-A-00/74718</text></B561><B561><text>WO-A-01/94585</text></B561><B561><text>WO-A-91/09967</text></B561><B561><text>WO-A-92/15683</text></B561><B561><text>WO-A-94/29451</text></B561><B561><text>WO-A-96/04925</text></B561><B561><text>WO-A-98/19704</text></B561><B561><text>US-A- 5 714 350</text></B561><B562><text>S. LEUNG ET AL.: "Construction and characterization of a humanized, internalizing, B-cell (CD22)-specific, leukemia/lymphoma antibody, LL2." MOLECULAR IMMUNOLOGY, vol. 32, no. 17/18, December 1995 (1995-12), pages 1413-1427, XP000942678 Oxford, GB</text></B562><B562><text>S. LEUNG ET AL.: "Effect of Vk framework-1 glycosylation on the binding affinity of lymphoma-specific murine and chimeric LL2 antibodies and its potential use as a novel conjugation site." INTERNATIONAL JOURNAL OF CANCER, vol. 60, 1995, pages 534-538, XP002066554 New York, NY, USA</text></B562><B562><text>I. BENHAR ET AL.: "Mutations of two lysine residues in the CDR loops of a recombinant immunotoxin that reduce its sensitivity to chemical derivatization." BIOCONJUGATE CHEMISTRY, vol. 5, July 1994 (1994-07), pages 321-326, XP000564453 Washington, DC, USA</text></B562><B562><text>T. VAUGHAN ET AL.: "Human antibodies by design." NATURE BIOTECHNOLOGY, vol. 16, June 1998 (1998-06), pages 535-539, XP000941675 New York, NY, USA cited in the application</text></B562><B562><text>J. CARNAHAN ET AL.: "Epratuzumab, a humanized monoclonal antibody targeting CD22: characterization of in vitro properties." CLINICAL CANCER RESEARCH, vol. 9, no. suppl., 1 September 2003 (2003-09-01), pages 3982S-3990S,</text></B562><B562><text>J. DIJOSEPH ET AL.: "Antibody-targeted chemotherapy of B-cell lymphoma using calicheamicin conjugated to murine or humanized antibody against CD22." CANCER IMMUNOLOGY &amp; IMMUNOTHERAPY, vol. 54, 2005, pages 11-24,</text></B562><B562><text>J. DIJOSEPH ET AL.: "Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies." BLOOD, vol. 103, no. 5, 1 March 2004 (2004-03-01), pages 1807-1814,</text></B562><B562><text>S. VAN ROSSENBERG ET AL.: "A structure-function study of ligand recognition by CD22beta." THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 16, 20 April 2001 (2001-04-20), pages 12967-12973, U.S.A.</text></B562><B562><text>J. BROWNING: "B cells move to centre stage: Novel opportunities for autoimmune disease treatment." NATURE REVIEWS DRUG DISCOVERY, vol. 5, no. 7, July 2006 (2006-07), pages 564-576,</text></B562></B560></B500><B700><B720><B721><snm>POPPLEWELL, Andrew George</snm><adr><str>Celltech R &amp; D Limited,
208 Bath Road</str><city>Slough,
Berkshire SL1 3WE</city><ctry>GB</ctry></adr></B721><B721><snm>TICKLE, Simon Peter</snm><adr><str>Celltech R &amp; D Limited,
208 Bath Road</str><city>Slough,
Berkshire SL1 3WE</city><ctry>GB</ctry></adr></B721><B721><snm>LADYMAN, Heather Margaret</snm><adr><str>Celltech R &amp; D Limited,
208 Bath Road</str><city>Slough,
Berkshire SL1 3WE</city><ctry>GB</ctry></adr></B721></B720><B730><B731><snm>UCB Pharma, S.A.</snm><iid>100953863</iid><irf>P030498EP:CPM</irf><adr><str>Allée de La Recherche 60</str><city>1070 Brussels</city><ctry>BE</ctry></adr></B731></B730><B740><B741><snm>Mercer, Christopher Paul</snm><sfx>et al</sfx><iid>100022025</iid><adr><str>Carpmaels &amp; Ransford LLP 
One Southampton Row</str><city>London
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