(19)

(11)

EP 1 504 089 A2

(12)

(88) Date of publication A3: 29.04.2004 (43) Date of publication: 09.02.2005 Bulletin 2005/06 (21) Application number: 03720295.9 (22) Date of filing: 15.05.2003

(51) International Patent Classification (IPC)7: C12N 9/00, C07K 16/42, C12N 15/12, C07K 16/28, C07K 16/00, A61K 39/35, A61K 39/36, G01N 33/53, A61P 37/08 (86) International application number: PCT/DK2003/000322 (87) International publication number: WO 2003/096869 (27.11.2003 Gazette 2003/48)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 16.05.2002 DK 200200756 16.05.2002 US 381440 P (71) Applicant: ALK ABELL A/S 2970 Horsholm (DK)	(72) Inventors: HOLM, Jens DK-2200 Copenhagen N (DK) FERRERAS, Mercedes DK-2100 Copenhagen Ö (DK) (74) Representative: Olsen, Lars Pallisgaard et al Zacco Denmark A/SHans Bekkevolds Allé 7 2900 Hellerup 2900 Hellerup (DK)