(19)
(11) EP 1 505 985 A1

(12)

(43) Date of publication:
16.02.2005 Bulletin 2005/07

(21) Application number: 03726785.3

(22) Date of filing: 09.05.2003
(51) International Patent Classification (IPC)7A61K 31/60, A61K 31/50, A61K 31/4418, A61K 31/42, A61K 31/415, A61K 31/341, A61K 31/196
(86) International application number:
PCT/US2003/014778
(87) International publication number:
WO 2003/094924 (20.11.2003 Gazette 2003/47)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
AL LT LV MK

(30) Priority: 10.05.2002 US 388660 P

(71) Applicant: Merck & Co., Inc.
Rahway,New Jersey 07065-0907 (US)

(72) Inventors:
  • HUNT, Richard, H.
    Rahway, NJ 07065-0907 (US)
  • SIMON, Thomas, J.
    Rahway, NJ 07065-0907 (US)

(74) Representative: Buchan, Gavin MacNicol 
Merck & Co., Inc.,European Patent Department,Terlings Park,Eastwick Road
Harlow,Essex CM20 2QR
Harlow,Essex CM20 2QR (GB)

   


(54) COMBINATION THERAPY FOR TREATING CYCLOOXYGENASE-2 MEDIATED DISEASES IN PATIENTS AT RISK OF THROMBOTIC CARDIOVASCULAR EVENTS