(19)

(11)

EP 1 506 020 A2

(12)

(88) Date of publication A3: 23.09.2004 (43) Date of publication: 16.02.2005 Bulletin 2005/07 (21) Application number: 03751760.4 (22) Date of filing: 19.05.2003

(51) International Patent Classification (IPC)7: A61K 48/00, C07H 21/00, C12Q 1/68 (86) International application number: PCT/US2003/015643 (87) International publication number: WO 2004/020577 (11.03.2004 Gazette 2004/11)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR (30) Priority: 23.05.2002 US 382842 P (71) Applicant: Mirus Corporation Madison, WI 53719 (US)	(72) Inventors: LEWIS, David, L. Madison, WI 53704 (US) ROZEMA, David, B. Madison, WI 53711 (US) WOLFF, Jon, A. Madison, WI 53705 (US) HAGSTROM, James, E. Middleton, WI 53562 (US) HERWEIJER, Hans Madison, WI 53719 (US) (74) Representative: Van Someren, Petronella F. H. M.  Arnold & Siedsma,Sweelinckplein 1 2517 GK The Hague 2517 GK The Hague (NL)