(19)
(11) EP 1 506 233 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
24.09.2014 Bulletin 2014/39

(45) Mention of the grant of the patent:
02.04.2014 Bulletin 2014/14

(21) Application number: 03727868.6

(22) Date of filing: 08.05.2003
(51) International Patent Classification (IPC): 
C07K 14/76(2006.01)
A23J 1/20(2006.01)
A61K 38/38(2006.01)
A61K 35/20(2006.01)
 A23L 1/305(2006.01)
A23J 3/08(2006.01)
A61K 47/12(2006.01)
(86) International application number:
PCT/IB2003/002366
(87) International publication number:
WO 2003/095490 (20.11.2003 Gazette 2003/47)

(54)

ACTIVE COMPLEX OF ALPHA-LACTALBUMIN (HAMLET) AND COFACTOR

AKTIVER KOMPLEX VON ALPHA-LACTALBUMIN (HAMLET) UND KOFAKTOR

COMPLEXE ACTIF D'ALPHA-LACTALBUMINE (HAMLET) ET CO-FACTEUR

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

(30) Priority: 08.05.2002 GB 0210464

(43) Date of publication of application:
16.02.2005 Bulletin 2005/07

(73) Proprietor: Nya Hamlet Pharma AB
2100 Copenhagen Ø (DK)

(72) Inventor:
  • SVANBORG, Catherine
    S-222 29 Lund (SE)

(74) Representative: Greaves, Carol Pauline et al
C P Greaves & Co 80 Church Road Winscombe
North Somerset BS25 1BP
North Somerset BS25 1BP (GB)


(56) References cited: : 
WO-A-01/77137
WO-A-99/27967
 WO-A-99/26979
   
  • SVANBORG CATHARINA ET AL: "HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects." ADVANCES IN CANCER RESEARCH. UNITED STATES 2003, vol. 88, 2003, pages 1-29, XP002254552 ISSN: 0065-230X
  • M. SVENSSON ET AL: "Conversion of alpha-lactalbumin to a protein inducing apoptosis" PNAS, vol. 97, no. 8, 11 April 2000 (2000-04-11), pages 4221-4226, XP002254553
  • KÖHLER C ET AL: "A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria." EUROPEAN JOURNAL OF BIOCHEMISTRY / FEBS. GERMANY JAN 2001, vol. 268, no. 1, January 2001 (2001-01), pages 186-191, XP002254554 ISSN: 0014-2956
  • POLVERINO DE LAURETO PATRIZIA ET AL: "Molten globule of bovine alpha-lactalbumin at neutral pH induced by heat, trifluoroethanol, and oleic acid: a comparative analysis by circular dichroism spectroscopy and limited proteolysis." PROTEINS. UNITED STATES 15 NOV 2002, vol. 49, no. 3, 15 November 2002 (2002-11-15), pages 385-397, XP002254555 ISSN: 1097-0134
  • SVENSSON MALIN ET AL: "Hamlet--a complex from human milk that induces apoptosis in tumor cells but spares healthy cells." ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. UNITED STATES 2002, vol. 503, 2002, pages 125-132, XP002254556 ISSN: 0065-2598
  • RAMMER PAUL ET AL: "BAMLET Activates a Lysosomal Cell Death Program in Cancer Cells", January 2010 (2010-01), MOLECULAR CANCER THERAPEUTICS, VOL. 9, NR. 1, PAGE(S) 24-32 ISSN: 1535-7163
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).