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<ep-patent-document id="EP03727868B8W1" file="EP03727868W1B8.xml" lang="en" country="EP" doc-number="1506233" kind="B8" correction-code="W1" date-publ="20140924" status="c" dtd-version="ep-patent-document-v1-4">
<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESI....FIRO..CY..TRBGCZEEHU..SK....................................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>DIM360 Ver 2.41 (21 Oct 2013) -  2999001/0</B007EP></eptags></B000><B100><B110>1506233</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20140924</date></B140><B150><B151>W1</B151><B153>72</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>03727868.6</B210><B220><date>20030508</date></B220><B240><B241><date>20041208</date></B241><B242><date>20071128</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>0210464</B310><B320><date>20020508</date></B320><B330><ctry>GB</ctry></B330></B300><B400><B405><date>20140924</date><bnum>201439</bnum></B405><B430><date>20050216</date><bnum>200507</bnum></B430><B450><date>20140402</date><bnum>201414</bnum></B450><B452EP><date>20131029</date></B452EP><B480><date>20140924</date><bnum>201439</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>C07K  14/76        20060101AFI20031127BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A23L   1/305       20060101ALI20031127BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>A23J   1/20        20060101ALI20031127BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>A23J   3/08        20060101ALI20031127BHEP        </text></classification-ipcr><classification-ipcr sequence="5"><text>A61K  38/38        20060101ALI20031127BHEP        </text></classification-ipcr><classification-ipcr sequence="6"><text>A61K  47/12        20060101ALI20031127BHEP        </text></classification-ipcr><classification-ipcr sequence="7"><text>A61K  35/20        20060101ALN20031127BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>AKTIVER KOMPLEX VON ALPHA-LACTALBUMIN (HAMLET) UND KOFAKTOR</B542><B541>en</B541><B542>ACTIVE COMPLEX OF ALPHA-LACTALBUMIN (HAMLET) AND COFACTOR</B542><B541>fr</B541><B542>COMPLEXE ACTIF D'ALPHA-LACTALBUMINE (HAMLET) ET CO-FACTEUR</B542></B540><B560><B561><text>WO-A-01/77137</text></B561><B561><text>WO-A-99/26979</text></B561><B561><text>WO-A-99/27967</text></B561><B562><text>SVANBORG CATHARINA ET AL: "HAMLET kills tumor cells by an apoptosis-like mechanism--cellular, molecular, and therapeutic aspects." ADVANCES IN CANCER RESEARCH. UNITED STATES 2003, vol. 88, 2003, pages 1-29, XP002254552 ISSN: 0065-230X</text></B562><B562><text>M. SVENSSON ET AL: "Conversion of alpha-lactalbumin to a protein inducing apoptosis" PNAS, vol. 97, no. 8, 11 April 2000 (2000-04-11), pages 4221-4226, XP002254553</text></B562><B562><text>KÖHLER C ET AL: "A folding variant of human alpha-lactalbumin induces mitochondrial permeability transition in isolated mitochondria." EUROPEAN JOURNAL OF BIOCHEMISTRY / FEBS. GERMANY JAN 2001, vol. 268, no. 1, January 2001 (2001-01), pages 186-191, XP002254554 ISSN: 0014-2956</text></B562><B562><text>POLVERINO DE LAURETO PATRIZIA ET AL: "Molten globule of bovine alpha-lactalbumin at neutral pH induced by heat, trifluoroethanol, and oleic acid: a comparative analysis by circular dichroism spectroscopy and limited proteolysis." PROTEINS. UNITED STATES 15 NOV 2002, vol. 49, no. 3, 15 November 2002 (2002-11-15), pages 385-397, XP002254555 ISSN: 1097-0134</text></B562><B562><text>SVENSSON MALIN ET AL: "Hamlet--a complex from human milk that induces apoptosis in tumor cells but spares healthy cells." ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. UNITED STATES 2002, vol. 503, 2002, pages 125-132, XP002254556 ISSN: 0065-2598</text></B562><B562><text>RAMMER PAUL ET AL: "BAMLET Activates a Lysosomal Cell Death Program in Cancer Cells", January 2010 (2010-01), MOLECULAR CANCER THERAPEUTICS, VOL. 9, NR. 1, PAGE(S) 24-32 ISSN: 1535-7163</text></B562></B560></B500><B700><B720><B721><snm>SVANBORG, Catherine</snm><adr><str>St. Mansgatan 4</str><city>S-222 29 Lund</city><ctry>SE</ctry></adr></B721></B720><B730><B731><snm>Nya Hamlet Pharma AB</snm><iid>100999917</iid><adr><str>c/o NatImmune A/S 
Fruebjergvej 3</str><city>2100 Copenhagen Ø</city><ctry>DK</ctry></adr></B731></B730><B740><B741><snm>Greaves, Carol Pauline</snm><sfx>et al</sfx><iid>101335894</iid><adr><str>C P Greaves &amp; Co 
80 Church Road 
Winscombe</str><city>North Somerset BS25 1BP</city><ctry>GB</ctry></adr></B741></B740></B700><B800><B840><ctry>AT</ctry><ctry>BE</ctry><ctry>BG</ctry><ctry>CH</ctry><ctry>CY</ctry><ctry>CZ</ctry><ctry>DE</ctry><ctry>DK</ctry><ctry>EE</ctry><ctry>ES</ctry><ctry>FI</ctry><ctry>FR</ctry><ctry>GB</ctry><ctry>GR</ctry><ctry>HU</ctry><ctry>IE</ctry><ctry>IT</ctry><ctry>LI</ctry><ctry>LU</ctry><ctry>MC</ctry><ctry>NL</ctry><ctry>PT</ctry><ctry>RO</ctry><ctry>SE</ctry><ctry>SI</ctry><ctry>SK</ctry><ctry>TR</ctry></B840><B860><B861><dnum><anum>IB2003002366</anum></dnum><date>20030508</date></B861><B862>en</B862></B860><B870><B871><dnum><pnum>WO2003095490</pnum></dnum><date>20031120</date><bnum>200347</bnum></B871></B870><B880><date>20050216</date><bnum>200507</bnum></B880></B800></SDOBI>
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