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<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESI....FIRO..CY..TRBGCZEEHU..SK....................................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>DIM360 Ver 2.15 (14 Jul 2008) -  2999001/0</B007EP></eptags></B000><B100><B110>1507529</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20100224</date></B140><B150><B151>W1</B151><B153>73</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>03732397.9</B210><B220><date>20030516</date></B220><B240><B241><date>20041217</date></B241><B242><date>20050407</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>381547 P</B310><B320><date>20020517</date></B320><B330><ctry>US</ctry></B330></B300><B400><B405><date>20100224</date><bnum>201008</bnum></B405><B430><date>20050223</date><bnum>200508</bnum></B430><B450><date>20090422</date><bnum>200917</bnum></B450><B452EP><date>20081114</date></B452EP><B472><B475><date>20090531</date><ctry>MC</ctry></B475></B472><B480><date>20100224</date><bnum>201008</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>A61K  31/4184      20060101AFI20031203BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A61K  31/19        20060101ALI20031203BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>C07D 401/12        20060101ALI20031203BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>A61K  31/44        20060101ALI20031203BHEP        </text></classification-ipcr><classification-ipcr sequence="5"><text>A61K  31/196       20060101ALI20031203BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>KOMBINATION ENTHALTEND VALSARTAN, AMLODIPIN UND HYDROCHLOROTHIAZID</B542><B541>en</B541><B542>COMBINATION COMPRISING VALSARTAN, AMLODIPINE AND HYDROCHLOROTHIAZIDE</B542><B541>fr</B541><B542>COMBINAISON COMPRENANT VALSARTANE, AMLODIPINE ET HYDROCHLOROTHIAZIDE</B542></B540><B560><B561><text>WO-A-92/20342</text></B561><B561><text>DE-A- 10 004 651</text></B561><B561><text>DE-A- 19 820 151</text></B561><B561><text>US-A- 5 656 650</text></B561><B562><text>MACGREGOR G A ET AL: "THE EFFICACY OF CANDESARTAN: AN ANGIOTENSIN II TYPE I RECEPTOR ANTAGONIST ALONE OR IN COMBINATION WITH AMLODIPINE OR IN COMBINATION WITH AMLODIPINE AND HYDROCHLOROTHIAZIDE IN PATIENTS WITH MODERATE-TO-SEVERE ESSENTIAL HYPERTENSION" AMERICAN JOURNAL OF HYPERTENSION, NEW YORK, NY, US, vol. 10, no. 4, PART 2, April 1997 (1997-04), page 112A XP000869500</text></B562><B562><text>MACGREGOR G A ET AL: "Efficacy of candesartan cilexetil alone or in combination with amlodipine and hydrochlorothiazide in moderate-to-severe hypertension" HYPERTENSION 2000 UNITED STATES, vol. 36, no. 3, 2000, pages 454-460, XP002251650 ISSN: 0194-911X</text></B562><B562><text>OPARIL SUZANNE ET AL: "Efficacy and safety of Losartan/Hydrochlorothiazide in patients with severe hypertension." AMERICAN JOURNAL OF CARDIOLOGY, vol. 87, no. 6, 15 March 2001 (2001-03-15), pages 721-726, XP002251651 ISSN: 0002-9149</text></B562><B562><text>OPARIL SUZANNE ET AL: "Efficacy, tolerability, and effects on quality of life of losartan, alone or with hydrochlorothiazide, versus amlodipine, alone or with hydrochlorothiazide, in patients with essential hypertension." CLINICAL THERAPEUTICS, vol. 18, no. 4, 1996, pages 608-625, XP002251652 ISSN: 0149-2918</text></B562><B562><text>OHNISHI K ET AL: "Influence of the angiotensin II receptor antagonist losartan on diuretic-induced metabolic effects in elderly hypertensive patients: Comparison with a calcium channel blocker." INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, vol. 39, no. 10, October 2001 (2001-10), pages 417-422, XP008020851 ISSN: 0946-1965</text></B562><B562><text>SONG J C, WHITE M: "Pharmacologic, pharmacokinetic, and therapeutic differences among angiotensin II receptor antagonists" PHARMACOTHERAPY, vol. 20, no. 2, 2000, pages 130-139,</text></B562><B562><text>[Online] Retrieved from the Internet: URL:http://www.pharma.us.novartis.com/news room/pressReleases/releaseDetail.jsp?PRID= 1996&gt;</text></B562><B562><text>WELLINGTON K, FAULDS D M: "Valsartan/hydrochlorothiazide: a review of its pharmacology, therapeutic efficacy and place in the management of hypertension" DRUGS, vol. 62, no. 13, 2002, pages 1983-2005,</text></B562></B560></B500><B700><B720><B721><snm>SHETTY, Suraj, Shivappa</snm><adr><str>12 Spring Street</str><city>Far Hills, NJ 07931</city><ctry>US</ctry></adr></B721><B721><snm>WEBB, Randy, Lee</snm><adr><str>17 Honeyman Drive</str><city>Flemington, NJ 08822</city><ctry>US</ctry></adr></B721></B720><B730><B731><snm>Novartis AG</snm><iid>02240429</iid><irf>PC/4-32495A/USN</irf><adr><str>Lichtstrasse 35</str><city>4056 Basel</city><ctry>CH</ctry></adr><B736EP><ctry>TR</ctry><ctry>BE</ctry><ctry>BG</ctry><ctry>CH</ctry><ctry>CY</ctry><ctry>CZ</ctry><ctry>DE</ctry><ctry>DK</ctry><ctry>EE</ctry><ctry>ES</ctry><ctry>FI</ctry><ctry>FR</ctry><ctry>GB</ctry><ctry>GR</ctry><ctry>HU</ctry><ctry>IE</ctry><ctry>IT</ctry><ctry>LI</ctry><ctry>LU</ctry><ctry>MC</ctry><ctry>NL</ctry><ctry>PT</ctry><ctry>RO</ctry><ctry>SE</ctry><ctry>SI</ctry><ctry>SK</ctry></B736EP></B731><B731><snm>Novartis Pharma GmbH</snm><iid>04273610</iid><irf>PC/4-32495A/USN</irf><adr><str>Brunner Strasse 59</str><city>1230 Wien</city><ctry>AT</ctry></adr><B736EP><ctry>AT</ctry></B736EP></B731></B730><B740><B741><snm>de Weerd, Petrus G.W.</snm><sfx>et al</sfx><iid>00092224</iid><adr><str>Novartis International AG 
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