(19)

(11)

EP 1 507 793 A2

(12)

(88) Date of publication A3: 27.05.2004 (43) Date of publication: 23.02.2005 Bulletin 2005/08 (21) Application number: 02786413.1 (22) Date of filing: 16.10.2002

(51) International Patent Classification (IPC)7: C07K 2/00, C07K 14/00, C07K 14/52, A61K 38/16 (86) International application number: PCT/US2002/032910 (87) International publication number: WO 2003/033658 (24.04.2003 Gazette 2003/17)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR (30) Priority: 17.10.2001 US 329508 P 18.10.2001 US 329747 P 31.10.2001 US 330835 P 16.11.2001 US 331478 P 07.12.2001 US 336726 P 01.04.2002 US 368548 P (71) Applicant: Human Genome Sciences, Inc. Rockville, MD 20850 (US)	(72) Inventors: YU, Guo-Liang Berkeley, CA 94705 (US) EBNER, Reinhard Gaithersburg, MD 20878 (US) NI, Jian Germantown, MD 20874 (US) ROSEN, Craig, A. Laytonsville, MD 20882 (US) LAIRD, Michael, W. Germantown, MD 20874 (US) ULLRICH, Stephen Rockville, MD 20853 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)