(19)

(11)

EP 1 509 086 A2

(12)

(88) Date of publication A3: 01.04.2004 (43) Date of publication: 02.03.2005 Bulletin 2005/09 (21) Application number: 03734032.0 (22) Date of filing: 16.05.2003

(51) International Patent Classification (IPC)7: A01N 63/00, A01N 37/18, A01N 43/04, C12N 5/00, C12N 15/00, C12N 15/63, C07H 21/02, C07H 21/04 (86) International application number: PCT/US2003/015280 (87) International publication number: WO 2003/097799 (27.11.2003 Gazette 2003/48)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 17.05.2002 US 380853 P (71) Applicants: Eastern Virginia Medical School Norfolk, VA 23501-6006 (US) THE UNIVERSITY OF VIRGINIA PATENT FOUNDATION Charlottesville,VA 22903 (US)	(72) Inventors: SEMMES, Oliver, John, IV Chesapeake, VA 23322 (US) KUPFER, Gary, Michael Charlottesville, VA 22901 (US) (74) Representative: Lee, Nicholas John et al Kilburn & Strode,20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)