(19)
(11) EP 1 511 752 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
18.04.2007 Bulletin 2007/16

(45) Mention of the grant of the patent:
13.09.2006 Bulletin 2006/37

(21) Application number: 03730480.5

(22) Date of filing: 28.05.2003
(51) International Patent Classification (IPC): 
C07D 491/22(2006.01)
A61K 31/47(2006.01)
 C07D 471/14(2006.01)
(86) International application number:
PCT/IT2003/000328
(87) International publication number:
WO 2003/101995 (11.12.2003 Gazette 2003/50)

(54)

CAMPTOTHECINS WITH A MODIFIED LACTONE RING

CAMPTOTHECINE MIT MODIFIZIERTEM LACTONRING

CAMPTOTHECINES A CYCLE LACTONE MODIFIE

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
AL LT LV MK

(30) Priority: 31.05.2002 IT RM20020305

(43) Date of publication of application:
09.03.2005 Bulletin 2005/10

(60) Divisional application:
06116366.3 / 1719775

(73) Proprietors:
  • SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.
    00144 Roma (IT)
  • ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI
    I-20133 Milano (IT)

(72) Inventors:
  • MARZI, Mauro
    Via Pontina, km 30,400 I-00040 Pomezia (IT)
  • MARASTONI, Elena
    I-43100 Parma (IT)
  • PENCO, Sergio
    I-20153 Milan (IT)
  • PISANO, Claudio
    Via Pontina Km. 30,400 I-00040 Pomezia (IT)
  • TINTI, Maria O.
    Via Pontina, km 30,400 I- 00040 Pomezia (IT)
  • VESCI, Loredana
    Via Pontina, km 30,400 I-00040 Pomezia (IT)
  • ZUNINO, Franco
    Via Venezian, 1 I-20133 Milan (IT)
  • VERGANI, Domenico
    Via Pontina, Km.30,400, 00040 Pomezia (IT)
  • DANELLI, Tamara
    Via Pontina, Km. 30,400, 00040 Pomezia (IT)
  • CABRI, Walter
    Via Pontina, Km. 30,400, I-00040 Pomezia (IT)
  • ALPEGIANI, Marco
    Via Pontina, Km. 30,400, I-00040 Pomezia (IT)
  • PATRICIO, Martin Gomez
    Via Pontina, Km. 30,400, I-00040 Pomezia (IT)

(74) Representative: Spadaro, Marco 
Studio Associato LEONE & SPADARO Viale Europa, 15
00144 Roma
00144 Roma (IT)


(56) References cited: : 
EP-A- 1 044 977
US-A1- 2001 008 939
 WO-A-97/00876
   
  • DALLAVALLE S; MERLINI L; PENCO S; ZUNINO F: "Perspecivs in camptothecin development" EXPERT OPINION ON THERAPEUTIC PATENTS , vol. 12, no. 6, 2002, pages 837-844, XP002251117
  • DAVID BOM, DENNIS P. CURRAN, ASHOK J.CHAVAN,STEFAN KRUSZEWSKI,STEPHEN G. ZIMMER, KIMBERLY A. FRALEY, AND THOMAS G.BURKE: "Novel A,B,E-Ring-Modified Camptothecins Displayin High Lipophilicity and Markedly improved Human Blood Stabilities" JOURNAL OF MEDICINAL CHEMISTRY , vol. 42, - 1999 pages 3018-3022, XP002251118
  • HERTZBERG R P ET AL: "Modification of the hydroxy lactone ring of camptothecin: Inhibition of mammalian topoisomerase I and biological activity" JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 32, no. 3, 1989, pages 715-720, XP002014409 ISSN: 0022-2623
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).