(19)

(11)

EP 1 513 522 A2

(12)

(88) Date of publication A3: 20.01.2005 (43) Date of publication: 16.03.2005 Bulletin 2005/11 (21) Application number: 03710713.3 (22) Date of filing: 21.01.2003

(51) International Patent Classification (IPC)7: A61K 31/41, A61K 31/44, A61K 31/53, A61K 31/415 (86) International application number: PCT/US2003/001881 (87) International publication number: WO 2003/062392 (31.07.2003 Gazette 2003/31)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 18.01.2002 US 350445 P 18.01.2002 US 350446 P 18.01.2002 US 350447 P 18.01.2002 US 350448 P (71) Applicant: SRI INTERNATIONAL Menlo Park,California 94025-3493 (US)	(72) Inventors: SHANKAR, Geetha Palo Alto, CA 94303 (US) SOLOW-CORDERO, David  (US) SPENCER, Juliet, V. San Mateo, CA 94403 (US) GLUCHOWSKI, Charles Danville, CA 94506 (US) (74) Representative: Killin, Stephen James  Venner Shipley LLP20 Little Britain London EC1A 7DH London EC1A 7DH (GB)