(19)
(11) EP 1 513 559 A1

(12)

(43) Date of publication:
16.03.2005 Bulletin 2005/11

(21) Application number: 03741818.3

(22) Date of filing: 23.05.2003
(51) International Patent Classification (IPC)7A61K 48/00, C12N 15/63
(86) International application number:
PCT/US2003/016541
(87) International publication number:
WO 2003/099341 (04.12.2003 Gazette 2003/49)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
AL LT LV MK

(30) Priority: 28.05.2002 US 156670
24.03.2003 US 395709

(71) Applicant: Advisys, Inc.
The Woodlands, TX 77381 (US)

(72) Inventors:
  • DRAGHIA-AKLI, Ruxandra
    Houston, TX 77035 (US)
  • CARPENTER, Robert, H.
    Bastrop, TX 78602 (US)
  • KERN, Douglas, R.
    The Woodlands, TX 77381 (US)
  • HILL, Leigh, Anne
    Houston, TX 77035 (US)
  • ATTRA, Heather
    Houston, TX 77035 (US)
  • HEBEL, Henry
    The Woodlands, TX 77382 (US)

(74) Representative: Fisher, Adrian John 
CARPMAELS & RANSFORD43-45 Bloomsbury Square
London WC1A 2RA
London WC1A 2RA (GB)

   


(54) INCREASED DELIVERY OF A NUCLEIC ACID CONSTRTUCT IN VIVO BY THE POLY-L-GLUTAMATE (PLG) SYSTEM