(19)

(11)

EP 1 513 951 A2

(12)

(88) Date of publication A3: 29.12.2004 (43) Date of publication: 16.03.2005 Bulletin 2005/11 (21) Application number: 03726880.2 (22) Date of filing: 15.05.2003

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/US2003/015313 (87) International publication number: WO 2003/097802 (27.11.2003 Gazette 2003/48)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 16.05.2002 US 380912 P (71) Applicant: Avalon Pharmaceuticals Germantown,Maryland 20876 (US)	(72) Inventors: WEAVER, Zoe New Market, MD 21774 (US) EBNER, Reinhard Gaithersburg, MD 20878 (US) (74) Representative: Ruffles, Graham Keith  Marks & Clerk66-68 Hills Road Cambridge,Cambridgeshire, CB2 1LA Cambridge,Cambridgeshire, CB2 1LA (GB)