CARBOCYCLIC NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE - Patent 1515971

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EP 1 515 971 A2

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(88)	Date of publication A3:
	07.10.2004

(43)	Date of publication:
	23.03.2005 Bulletin 2005/12

(21)	Application number: 03760371.9

(22)	Date of filing: 14.06.2003

(51)	International Patent Classification (IPC)⁷: C07D 473/00, C07D 473/02, C07D 473/04, C07D 473/16, C07D 473/18, C07D 473/20, C07D 473/22, C07D 473/24, C07D 473/26, C07D 473/28, C07D 473/30, C07D 473/32, C07D 473/34, C07D 473/36, C07D 473/38, C07D 473/40, A61K 31/52, A61K 31/522, A61P 31/14

(86)	International application number:
	PCT/US2003/018841

(87)	International publication number:
	WO 2003/105770 (24.12.2003 Gazette 2003/52)

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
	Designated Extension States:
	AL LT LV MK

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Priority:

17.06.2002 US 389161 P

(71)	Applicants:
	Merck & Co., Inc. Rahway,New Jersey 07065-0907 (US) ISIS PHARMACEUTICALS, INC. Carlsbad, CA 92008 (US)

(72)	Inventors:
	BHAT, Balkrishen Carlsbad, CA 92008 (US) BHAT, Neelima Carlsbad, CA 92008 (US) DANDE, Prasad Carlsbad, CA 92008 (US) ELDRUP, Anne, B. Carlsbad, CA 92008 (US) OLSEN, David, B. Rahway, NJ 07065-0907 (US) MACCOSS, Malcolm Rahway, NJ 07065-0907 (US)

(74)	Representative: Man, Jocelyn et al
	Merck & Co.,Inc.,European Patent Department,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)

(54)	CARBOCYCLIC NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE