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EP 1 517 917 A2

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(88) Date of publication A3: 27.01.2005 (43) Date of publication: 30.03.2005 Bulletin 2005/13 (21) Application number: 01995166.4 (22) Date of filing: 16.11.2001

(51) International Patent Classification (IPC)7: C07K 14/435 (86) International application number: PCT/US2001/043490 (87) International publication number: WO 2002/042417 (30.05.2002 Gazette 2002/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 20.11.2000 US 249981 P (71) Applicant: Merck & Co., Inc. Rahway,New Jersey 07065-0907 (US)	(72) Inventors: FOLANDER, Kimberly, L. Rahway, NJ 07065-0907 (US) MCKENNA, Edward, J. Rahway, NJ 07065-0907 (US) SWANSON, Richard, J. Rahway, NJ 07065-0907 (US) LIU, Yuan Rahway, NJ 07065-0907 (US) (74) Representative: Horgan, James Michael Frederic et al Merck & Co., Inc.European Patent DepartmentTerlings ParkEastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)