(19)

(11)

EP 1 517 997 A2

(12)

(88) Date of publication A3: 01.04.2004 (43) Date of publication: 30.03.2005 Bulletin 2005/13 (21) Application number: 03729139.0 (22) Date of filing: 23.05.2003

(51) International Patent Classification (IPC)7: C12Q 1/37, G01N 33/50, A61K 38/06, A61K 38/07, C09K 11/06, C07D 311/88 (86) International application number: PCT/US2003/016530 (87) International publication number: WO 2003/099780 (04.12.2003 Gazette 2003/49)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 24.05.2002 US 383363 P (71) Applicant: MOLECULAR DEVICES CORPORATION Sunnyvale,California 94089 (US)	(72) Inventors: DIWU, Zhenjun Sunnyvale, CA 94087 (US) LIAO, Jinfang Foster City, CA 94404 (US) WANG, Zhiqiang Sunnyvale, CA 94087 (US) (74) Representative: Harrison Goddard Foote  Belgrave HallBelgrave Street Leeds LS2 8DD Leeds LS2 8DD (GB)