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EP 1 519 723 A1

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(43) Date of publication: 06.04.2005 Bulletin 2005/14 (21) Application number: 03727245.7 (22) Date of filing: 27.05.2003

(51) International Patent Classification (IPC)7: A61K 31/426, A61K 31/427, A61K 31/433, A61P 3/04, A61P 3/10, C07D 277/42, C07D 417/04, C07D 277/60, C07D 417/12, C07D 285/12, C07D 285/16 (86) International application number: PCT/DK2003/000350 (87) International publication number: WO 2004/002480 (08.01.2004 Gazette 2004/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 27.06.2002 DK 200201006 17.12.2002 DK 200201927 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)

(72) Inventors: LAU, Jesper DK-3520 Farum (DK) CHRISTENSEN, Inge, Th ger DK-2800 Lyngby (DK) MADSEN, Peter DK-2880 Bagsv rd (DK) BLOCH, Paw DK-2630 Taastrup (DK) BEHRENS, Carsten DK-2200 Copenhagen N (DK) KODRA, János, Kodra DK-2100 Copenhagen (DK) NIELSEN, Poul, Enrico DK-4140 Borup (DK) Jorgensen, Anker.S. DK-2100 Kobenhavn (DK) (74) Representative: Nilsson, Karin Norvin  Novo Nordisk A/S,Corporate Patents,Novo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)