(19)

(11)

EP 1 520 021 A2

(12)

(88) Date of publication A3: 22.04.2004 (43) Date of publication: 06.04.2005 Bulletin 2005/14 (21) Application number: 03762317.0 (22) Date of filing: 01.07.2003

(51) International Patent Classification (IPC)7: C12N 15/11, A61K 31/7115, A61K 31/712, A61K 31/7125, A61P 35/00, A61P 3/00, A61P 31/12, A61P 9/10 (86) International application number: PCT/US2003/020865 (87) International publication number: WO 2004/003201 (08.01.2004 Gazette 2004/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR (30) Priority: 01.07.2002 US 392813 P (71) Applicant: Pharmacia Corporation Chesterfield, MO 63006 (US)	(72) Inventor: KANE, Christopher, D. Ballwin, MO 63011 (US) (74) Representative: Courgeon, Antoine  Pfizer PGRDDépartement Brevets23-25 avenue du Docteur Lannelongue F-75668 Paris Cedex 14 F-75668 Paris Cedex 14 (FR)