(19)

(11)

EP 1 520 023 A2

(12)

(88) Date of publication A3: 29.04.2004 (43) Date of publication: 06.04.2005 Bulletin 2005/14 (21) Application number: 03738307.2 (22) Date of filing: 03.07.2003

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/72, C07K 16/28, C12Q 1/68, G01N 33/53, G01N 33/50, C12N 5/10, A61K 38/17, A61K 39/00, A01K 67/027 (86) International application number: PCT/GB2003/002848 (87) International publication number: WO 2004/005346 (15.01.2004 Gazette 2004/03)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 03.07.2002 GB 0215406 (71) Applicant: Inpharmatica Limited London W1T 2NU (GB)

(72) Inventors: PHELPS , Christopher, Benjamin London W1T 2NU (GB) FAGAN, Richard, Joseph London W1T 2NU (GB) ALLEN, Kathryn, Elizabeth London W1T 2NU (GB) STANCOVSKI, Ilana London W1T 2NU (GB) PIERRON, Valerie, Nathalie London W1T 2NU (GB) PHILLIPS, Tom London W1T 2NU (GB) HUNT, Caroline, Ann London W1T 2NU (GB) ENAYAT, Zinat, Ellaheh London W1T 2NU (GB) ALLEN, Janet, Marjorie London W1T 2NU (GB) (74) Representative: Goodfellow, Hugh Robin  Carpmaels & Ransford,43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)