(19)

(11)

EP 1 520 040 A2

(12)

(88) Date of publication A3: 18.03.2004 (43) Date of publication: 06.04.2005 Bulletin 2005/14 (21) Application number: 03729909.6 (22) Date of filing: 20.06.2003

(51) International Patent Classification (IPC)7: C12Q 1/68, C12N 15/10, C12P 21/02, C07H 21/00 (86) International application number: PCT/DK2003/000417 (87) International publication number: WO 2004/001042 (31.12.2003 Gazette 2004/01)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 20.06.2002 WO PCT/DK02/00419 20.06.2002 US 175539 19.12.2002 DK 200201953 20.12.2002 US 434664 P (71) Applicant: Nuevolution A/S 2100 Copenhagen (DK)	(72) Inventors: FRESKGARD, Per-Ola S-235 93 Vellinge (SE) PEDERSEN, Henrik DK-2880 Bagsvaerd (DK) (74) Representative: HOEIBERG A/S  European Patent & Trademark AttorneysStore Kongensgade 59A 1264 Copenhagen K 1264 Copenhagen K (DK)