(19)

(11)

EP 1 527 099 A2

(12)

(88) Date of publication A3: 26.08.2004 (43) Date of publication: 04.05.2005 Bulletin 2005/18 (21) Application number: 03767146.8 (22) Date of filing: 01.08.2003

(51) International Patent Classification (IPC)7: C07K 16/00, C07H 21/04, C12N 15/00, A61K 39/395 (86) International application number: PCT/US2003/024336 (87) International publication number: WO 2004/013158 (12.02.2004 Gazette 2004/07)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 01.08.2002 US 211948 02.08.2002 US 319446 P (71) Applicant: Northwestern University Evanston, IL 60201 (US)	(72) Inventors: JARDETZKY, Theodore, S. Evanston, IL 60201 (US) WURZBURG, Beth, A. Evanston, IL 60201 (US) (74) Representative: Pilkington, Stephanie Joan  Eric Potter ClarksonPark View House58 The Ropewalk Nottingham NG1 5DD Nottingham NG1 5DD (GB)