(57) A system and method for performing rupture event scanning and other sensing operations
on a sample. The method includes providing a transducer (42,44,46,48) with an immobilized
binding partner material and a sample material disposed thereon. The sample material
is applied to the immobilized binding partner material so that, if components in the
sample material have sufficient affinity for the immobilized binding partner material,
bonds will form between at least some of such components and the immobilized binding
partner material. The method further includes accelerating the transducer (42,44,46,48)
to induce bond breakage, where such accelerating is performed by applying a drive
signal to the transducer (42,44,46,48). The drive signal includes a waveform having
multiple frequency components that are pre-selected based on expected resonance behavior
of the transducer (42,44,46,48). The method may also include analyzing an output response
of the transducer (42,44,46,48) in response to application of the drive signal.
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