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(11)

EP 1 532 140 A1

(12)

(43) Date of publication: 25.05.2005 Bulletin 2005/21 (21) Application number: 00941596.9 (22) Date of filing: 21.06.2000

(51) International Patent Classification (IPC)7: C07D 409/12, A61P 9/04, A61K 31/381, A61K 31/34 (86) International application number: PCT/US2000/017024 (87) International publication number: WO 2000/078754 (28.12.2000 Gazette 2000/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL (30) Priority: 21.06.1999 US 140352 P (71) Applicants: University of Maryland, Baltimore Baltimore, MD 21201 (US) Universidade Federal do Rio de Janeiro Ilhy Do FundaoRJ 21941-590 (BR)

(72) Inventors: ALBUQUERQUE, Edson, X. Baltimore, MD 21210 (US) DE BARREIRO, Eliezer J. CEP-20260-290 Rio de Janeiro (BR) SUDO, Roberto Takashi Rio de JaneiroRJ 22030-040 (BR) ARACAVA, Yasco RJ-22290-240 Rio de Janeiro (BR) CINTRA, Magner Monteiro Rio de Janeiro RJ-22430-210 (BR) MELO, Paulo de Assis Niteroi RJ-24220-110 (BR) NOEL, Francois Germain Rio De Janeiro RJ-21940-380 (BR) SUDO, Gisele Zapata Copacabana Rio de Janeiro RJ-22030-040 (BR) DA SILVA, Claudio Lucia Martins Rio de Janeiro RJ-20720-230 (BR) DE CASTRO, Newton Goncalves Rio de Janeiro RJ-22260-210 (BR) FERNANDES, Patricia Dias Rio de Janeiro RJ-20540-010 (BR) FRAGA, Carlos Alberto Manssour Rio de Janeiro RJ-20761-050 (BR) DE MIRANDA, Ana Luisa Palhares Petropolis RJ-25640-340 (BR) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)