(19)

(11)

EP 1 532 275 A2

(12)

(88) Date of publication A3: 12.08.2004 (43) Date of publication: 25.05.2005 Bulletin 2005/21 (21) Application number: 03771719.6 (22) Date of filing: 23.07.2003

(51) International Patent Classification (IPC)7: C12Q 1/68, C12P 19/34, C07H 21/02, C07H 21/04 (86) International application number: PCT/US2003/022936 (87) International publication number: WO 2004/011666 (05.02.2004 Gazette 2004/06)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 26.07.2002 US 398934 P (71) Applicant: Applera Corporation Foster City, CA 94404 (US)	(72) Inventor: ANDERSEN, Mark, R. San Mateo, CA 94403 (US) (74) Representative: Moran, Paula  OLSWANG90 High Holborn London WC1V 6XX London WC1V 6XX (GB)