(19)

(11)

EP 1 534 202 A1

(12)

(43) Date of publication: 01.06.2005 Bulletin 2005/22 (21) Application number: 03757353.2 (22) Date of filing: 05.06.2003

(51) International Patent Classification (IPC)7: A61F 13/00, A61F 2/00, A61K 9/00 (86) International application number: PCT/US2003/017736 (87) International publication number: WO 2003/103549 (18.12.2003 Gazette 2003/51)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 05.06.2002 US 385571 P (71) Applicant: UNIVERSITY OF FLORIDA Gainesville,Florida 32611-5500 (US)	(72) Inventors: CHAUHAN, Anuj Gainwsville, FL 32608 (US) GULSEN, Derya Gainesville, FL 32603 (US) (74) Representative: Jones, Nicholas Andrew  Withers & Rogers LLPGoldings House,2 Hays Lane London SE1 2HW London SE1 2HW (GB)