(19)

(11)

EP 1 534 317 A2

(12)

(88) Date of publication A3: 17.03.2005 (43) Date of publication: 01.06.2005 Bulletin 2005/22 (21) Application number: 02756157.0 (22) Date of filing: 10.06.2002

(51) International Patent Classification (IPC)7: A61K 38/16, A61K 48/00, A61K 39/395, C07K 14/435, C07K 16/32, C07H 21/04 (86) International application number: PCT/US2002/018478 (87) International publication number: WO 2002/100343 (19.12.2002 Gazette 2002/51)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.06.2001 US 296970 P (71) Applicant: Mandalmed, Inc. San Francisco, CA 94132 (US)	(72) Inventors: JARVIS, Gary, A.,MandalMed, Inc. San Francisco, CA 94132 (US) JOHN, Constance, M.,MandalMed, Inc. San Francisco, CA 94132 (US) LEFFLER, Hakon,MandalMed, Inc. San Francisco, CA 94132 (US) (74) Representative: Tombling, Adrian George et al Withers & Rogers LLPGoldings House,2 Hays Lane London SE1 2HW London SE1 2HW (GB)