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(11)

EP 1 534 332 A2

(12)

(88) Date of publication A3: 10.03.2005 (43) Date of publication: 01.06.2005 Bulletin 2005/22 (21) Application number: 03762258.6 (22) Date of filing: 30.06.2003

(51) International Patent Classification (IPC)7: A61K 39/395, G01N 33/574, C12N 5/06, C12N 5/16, C12N 15/09, C12N 15/13, C12P 21/00, C07K 16/00, C07H 21/04 (86) International application number: PCT/US2003/020602 (87) International publication number: WO 2004/003166 (08.01.2004 Gazette 2004/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 01.07.2002 US 189032 (71) Applicant: Savient Pharmaceuticals, Inc. East Brunswick, NJ 08816 (US)	(72) Inventors: LEVANON, Avigdor Revohot (IL) BEN-LEVY, Rachel 26 Benei Reem (IL) PLAKSIN, Daniel Rehovot (IL) SZANTON, Esther Rehovot (IL) HAGAI, Yocheved Rehovot (IL) HOCH MAR-CHAIM, Hagit Aseret (IL) (74) Representative: Mallalieu, Catherine Louise et al D Young & Co120 Holborn London EC1N 2DY London EC1N 2DY (GB)