(19)

(11)

EP 1 534 737 A2

(12)

(88) Date of publication A3: 07.04.2005 (43) Date of publication: 01.06.2005 Bulletin 2005/22 (21) Application number: 03728390.0 (22) Date of filing: 15.04.2003

(51) International Patent Classification (IPC)7: C07K 7/06, C07K 7/08, C07K 14/00, C07K 14/495, A61K 38/04, A61K 38/07, A61K 38/08, A61K 38/10, A61K 38/16 (86) International application number: PCT/US2003/011437 (87) International publication number: WO 2003/093293 (13.11.2003 Gazette 2003/46)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 29.04.2002 US 135946 (71) Applicant: Saint Louis University St. Louis, MO 63103 (US)	(72) Inventor: HUANG, Jung San St. Louis, MO 63132 (US) (74) Representative: Brasnett, Adrian Hugh et al Mewburn Ellis LLPYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)