(19)

(11)

EP 1 534 825 A2

(12)

(88) Date of publication A3: 07.04.2005 (43) Date of publication: 01.06.2005 Bulletin 2005/22 (21) Application number: 03711195.2 (22) Date of filing: 20.02.2003

(51) International Patent Classification (IPC)7: C12N 9/64 (86) International application number: PCT/US2003/005338 (87) International publication number: WO 2003/072724 (04.09.2003 Gazette 2003/36)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 22.02.2002 US 358873 P 22.02.2002 US 358875 P 08.03.2002 US 363020 P 12.04.2002 GB 0208404 (71) Applicant: Aventis Pharmaceuticals, Inc. Bridgwater, New Jersey 08807-2854 (US)	(72) Inventors: HAHN, Chang Princeton, NJ 08540 (US) LIU, Hong Bridgewater, NJ 08807 (US) (74) Representative: Bouvet, Philippe  Aventis Pharma S.A.Direction des Brevets,Tri LEO/14420, avenue Raymond Aron 92165 Antony Cedex 92165 Antony Cedex (FR)