(19)

(11)

EP 1 537 067 A2

(12)

(88) Date of publication A3: 15.04.2004 (43) Date of publication: 08.06.2005 Bulletin 2005/23 (21) Application number: 03785253.0 (22) Date of filing: 12.08.2003

(51) International Patent Classification (IPC)7: C07C 59/42 (86) International application number: PCT/US2003/025336 (87) International publication number: WO 2004/014835 (19.02.2004 Gazette 2004/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 12.08.2002 US 402798 P 12.08.2003 US 639714 (71) Applicant: BRIGHAM AND WOMEN'S HOSPITAL Boston,Massachusetts 02115 (US)	(72) Inventor: SERHAN, Charles, N. Needham, MA 02492 (US) (74) Representative: Strehl Schübel-Hopf & Partner  Maximilianstrasse 54 80538 München 80538 München (DE)