(19)
(11) EP 1 539 176 A1

(12)

(43) Date of publication:
15.06.2005 Bulletin 2005/24

(21) Application number: 03760686.0

(22) Date of filing: 24.06.2003
(51) International Patent Classification (IPC)7A61K 31/536, A61K 31/5415, A61P 19/02, C07D 279/08, C07D 265/26
(86) International application number:
PCT/EP2003/006601
(87) International publication number:
WO 2004/000322 (31.12.2003 Gazette 2004/01)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
AL LT LV MK

(30) Priority: 25.06.2002 WO PCT/EP02/08062

(71) Applicant: WARNER-LAMBERT COMPANY LLC
Morris Plains,NJ 07950 (US)

(72) Inventors:
  • GAUDILLIERE, Bernard,Pfizer Global and Rrch Devl.
    Sandwich, Kent CT13 9NJ (FR)
  • JACOBELLI, HenryPfizer Global&Research Developm.
    Sandwich,Kent CT13 9NJ (GB)

(74) Representative: Hirsch, Denise Marie 
PfizerEuropean Pharma Patent Department23-25, avenue du Docteur Lannelongue
75668 Paris Cedex 14
75668 Paris Cedex 14 (FR)

   


(54) THIAZINE AND OXAZINE DERIVATIVES AS MMP-13 INHIBITORS FOR TREATING ARTHRITIS