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EP 1 539 687 A1

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(43) Date of publication: 15.06.2005 Bulletin 2005/24 (21) Application number: 03787971.5 (22) Date of filing: 04.08.2003

(51) International Patent Classification (IPC)7: C07C 323/25, C07C 229/12, C07D 217/02, C07C 323/32, C07C 229/14, A61K 31/198, A61K 31/223, A61K 31/47 (86) International application number: PCT/IB2003/003708 (87) International publication number: WO 2004/016583 (26.02.2004 Gazette 2004/09)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 16.08.2002 GB 0219153 (71) Applicants: Pfizer Limited Sandwich,Kent CT13 9NJ (GB) GB  Blakemore, David Clive Sandwich,Kent CT13 9NJ (GB) AT BE BG CH CY CZ DE DK EE ES FI FR GR HU IE IT LU MC NL PT

(72) Inventors: BLAKEMORE, David Clive Sandwich,Kent CT13 9NJ (GB) BRYANS, Justin Stephen Sandwich,Kent CT13 9NJ (GB) MAW, Graham Nigel Sandwich,Kent CT13 9NJ (GB) RAWSON, David James Sandwich,Kent CT13 9NJ (GB) THOMPSON, Lisa Rosemary Sandwich,Kent CT13 9NJ (GB) CHU, Wai-Lam Alexis San Diego, CA 92121 (US) (74) Representative: Ruddock, Keith Stephen  Pfizer LimitedEuropean Patents Department,Ramsgate Road Sandwich,Kent CT13 9NJ Sandwich,Kent CT13 9NJ (GB)