(19)

(11)

EP 1 539 788 A2

(12)

(88) Date of publication A3: 21.04.2005 (43) Date of publication: 15.06.2005 Bulletin 2005/24 (21) Application number: 03711065.7 (22) Date of filing: 12.02.2003

(51) International Patent Classification (IPC)7: C07H 21/04, A61K 48/00, C12N 15/63 (86) International application number: PCT/US2003/004622 (87) International publication number: WO 2003/069311 (21.08.2003 Gazette 2003/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR (30) Priority: 12.02.2002 US 75028 12.02.2002 US 76248 (71) Applicant: Intronn, Inc. Rockville, MD 20850 (US)	(72) Inventors: MITCHELL, Lloyd, G. Bethesda, MA 20814 (US) GARCIA-BLANCO, Mariano, A. Durham, NC 27713 (US) PUTTARAJU, Madaiah Durham, NC 27713 (US) (74) Representative: Lucas, Brian Ronald et al Lucas & Co.135 Westhall Road Warlingham,Surrey CR6 9HJ Warlingham,Surrey CR6 9HJ (GB)