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EP 1 539 805 A2

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(88) Date of publication A3: 21.04.2005 (43) Date of publication: 15.06.2005 Bulletin 2005/24 (21) Application number: 02736898.4 (22) Date of filing: 15.05.2002

(51) International Patent Classification (IPC)7: C07K 14/00, C07K 16/00, C07H 21/02, A61K 39/395, A61K 38/00, A61K 48/00, C12Q 1/68, G01N 33/53 (86) International application number: PCT/US2002/015520 (87) International publication number: WO 2002/092842 (21.11.2002 Gazette 2002/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 15.05.2001 US 291118 P 31.10.2001 US 1469 14.12.2001 US 17666 (71) Applicant: Agensys, Inc. Santa Monica, CA 90404 (US)

(72) Inventors: JAKOBOVITS, Aya Beverly Hills, CA 90210 (US) FARIS, Mary Los Angeles, CA 90077 (US) RAITANO, Arthur, B. Los Angeles, CA 90064 (US) MORRISON, Robert, Kendall Santa Monica, CA 90403 (US) SAFFRAN, Douglas Encinitas, CA 92024 (US) GE, Wangmao Culver City, CA 90230 (US) CHALLITA-EID, Pia, M. Encino, CA 91436 (US) (74) Representative: Roques, Sarah Elizabeth  J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)