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EP 1 539 957 A1

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(43) Date of publication: 15.06.2005 Bulletin 2005/24 (21) Application number: 03793494.0 (22) Date of filing: 05.09.2003

(51) International Patent Classification (IPC)7: C12N 15/12, C12N 15/52, C12N 9/00, C07K 14/47, C07K 16/18, C07K 16/40, C07K 16/42, G01N 33/48, G01N 33/50, G01N 33/68 (86) International application number: PCT/AU2003/001164 (87) International publication number: WO 2004/022750 (18.03.2004 Gazette 2004/12)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 05.09.2002 AU 2002951346 07.11.2002 US 425218 P (71) Applicant: GARVAN INSTITUTE OF MEDICAL RESEARCH Darlinghurst, NSW 2010 (AU)

(72) Inventors: WATTS, Colin Avalon, New South Wales 2107 (AU) SAUNDERS, Darren Alexandria, New South Wales 2015 (AU) HENDERSON, Michelle Drummoyne, New South Wales 2047 (AU) CLANCY, Jennifer Stanmore, New South Wales 2048 (AU) HENSHALL, Susan Mosman, New South Wales 2088 (AU) SUTHERLAND, Robert Lindfield, New South Wales 2070 (AU) O'BRIEN, Philippa Woollahra, New South Wales 2025 (AU) (74) Representative: Bassil, Nicholas Charles et al Kilburn & Strode20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)