(19)

(11)

EP 1 542 733 A2

(12)

(88) Date of publication A3: 29.07.2004 (43) Date of publication: 22.06.2005 Bulletin 2005/25 (21) Application number: 03785119.3 (22) Date of filing: 08.08.2003

(51) International Patent Classification (IPC)7: A61K 49/00, A61K 38/08, A61K 38/12 (86) International application number: PCT/US2003/024994 (87) International publication number: WO 2004/015392 (19.02.2004 Gazette 2004/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 08.08.2002 US 402372 P 14.05.2003 US 740927 P (71) Applicant: Targeted Molecules Corporation San Diego, CA 92109 (US)	(72) Inventors: FAN, Xiao- Min San Diego, CA 92129 (US) LAZARIDES, Elias La Jolla, CA 92037 (US) WOODS, Catherine, Mary La Jolla, CA 92037 (US) (74) Representative: Winckels, J.H.F., Mr. Ir. et al Vereenigde,Johan de Wittlaan 7 2517 JR Den Haag 2517 JR Den Haag (NL)