(19)
(11) EP 1 544 294 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
19.03.2014 Bulletin 2014/12

(45) Mention of the grant of the patent:
10.04.2013 Bulletin 2013/15

(21) Application number: 03707180.0

(22) Date of filing: 28.02.2003
(51) International Patent Classification (IPC): 
C12N 15/09(2006.01)
C07H 11/04(2006.01)
 C07H 7/06(2006.01)
(86) International application number:
PCT/JP2003/002342
(87) International publication number:
WO 2004/007713 (22.01.2004 Gazette 2004/04)

(54)

NUCLEOSIDES OR NUCLEOTIDES HAVING NOVEL UNNATURAL BASES AND USE THEREOF

NUKLEOSIDE UND NUKLEOTIDE MIT NEUEN UNNATÜRLICHEN BASEN UND VERWENDUNG DAVON

NUCLEOSIDE OU NUCLEOTIDE AYANT UNE NOUVELLE BASE NON NATURELLE ET SON UTILISATION

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR

(30) Priority: 17.07.2002 JP 2002208568

(43) Date of publication of application:
22.06.2005 Bulletin 2005/25

(73) Proprietors:
  • RIKEN
    Wako-shi, Saitama 351-0198 (JP)
  • Japan Science and Technology Agency
    Kawaguchi-shi, Saitama 332-0012 (JP)

(72) Inventors:
  • HIRAO, Ichiro,
    Wako-shi, Saitama 351-0198 (JP)
  • YOKOYAMA, Shigeyuki,
    Yokohama-shi, Kanagawa 230-0045 (JP)
  • HIRAO, Michiko,
    Wako-shi, Saitama 351-0198 (JP)
  • MITSUI, Tsuneo
    Wako-shi, Saitama 351-0198 (JP)

(74) Representative: Denison, Christopher Marcus et al
Mewburn Ellis LLP 33 Gutter Lane
London EC2V 8AS
London EC2V 8AS (GB)


(56) References cited: : 
WO-A-01/16149
   
  • T. OHTSUKI ET AL.: "Unnatural base pairs for specific transcription" PNAS, vol. 98, 2001, pages 4922-4925, XP002546129
  • SILVERMAN D B ET AL: "MOLECULAR MOMENT SIMILARITY BETWEEN SEVERAL NUCLEOSIDE ANALOGS OF THYMIDINE AND THYMIDINE" JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, ADENINE PRESS, NEW YORK, NY, US, vol. 16, no. 6, 1 June 1999 (1999-06-01), pages 1169-1175, XP009050925 ISSN: 0739-1102
  • ICHIRO HIRAO ET AL.: 'Jinko enkitai no sosei iden ango no kakucho o mezashite' PROTEIN, NUCLEIC ACID AND ENZYME vol. 47, no. 14, November 2002, pages 1904 - 1913, XP002974101
  • HIRAO I. ET AL.: 'A unique unnatural base pair between a C analogue, pseudoisocytosine and an A analogue, 6-methoxypurine, in replication' BIOORGANIC & MEDICINAL CHEMISTRY LETTERS vol. 12, May 2002, pages 1391 - 1393, XP002974102
  • FUJIWARA T. ET AL.: 'Synthesis of 6-(2-thienyl) purine nucleoside derivatives that form unnatural base pairs with pyridin-2-one nucleosides' BIOORGANIC & MEDICINAL CHEMISTRY LETTERS vol. 11, 2001, pages 2221 - 2223, XP002974103
  • HIRANO I. ET AL.: 'An unnatural base pair for incorporating amino acids analogs into proteins' NATURE BIOTECH. vol. 20, February 2002, pages 177 - 182, XP001068466
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).