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(11)

EP 1 545 489 A1

(12)

(43) Date of publication: 29.06.2005 Bulletin 2005/26 (21) Application number: 03748971.3 (22) Date of filing: 24.07.2003

(51) International Patent Classification (IPC)7: A61K 31/165 (86) International application number: PCT/US2003/023088 (87) International publication number: WO 2004/009069 (29.01.2004 Gazette 2004/05)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 24.07.2002 US 398676 P 28.01.2003 US 443035 P (71) Applicant: Cypress Bioscience, Inc. San Diego, CA 92121 (US)	(72) Inventors: RAO, Srinivas, G. San Diego, CA 92131 (US) KRANZLER, Jay, D. La Jolla, CA 92037 (US) (74) Representative: Nilausen, Kim et al Zacco Denmark A/S,Hans Bekkevolds Allé 7 2900 Hellerup 2900 Hellerup (DK)