(19)

(11)

EP 1 545 491 A1

(12)

(43) Date of publication: 29.06.2005 Bulletin 2005/26 (21) Application number: 03787963.2 (22) Date of filing: 06.08.2003

(51) International Patent Classification (IPC)7: A61K 31/195, A61P 25/00, A61P 25/02 (86) International application number: PCT/IB2003/003546 (87) International publication number: WO 2004/016260 (26.02.2004 Gazette 2004/09)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 15.08.2002 GB 0219024 04.10.2002 GB 0223067 (71) Applicants: Pfizer Limited Sandwich,Kent CT13 9NJ (GB) GB  PFIZER INC. New York, N.Y. 10017 (US) AT BE BG CH CY CZ DE DK EE ES FI FR GR HU IE IT LU MC NL PT	(72) Inventors: BLAKEMORE, David Clive,Pfizer Global R & D Sandwich,Kent CT13 9NJ (GB) BRYANS, Justin, Stephen,Pfizer Global R & D Sandwich,Kent CT13 9NJ (GB) WILLIAMS, Sophie Caroline,Pfizer Global R & D Sandwich,Kent CT13 9NJ (GB) (74) Representative: Rudge, Andrew John  Pfizer LimitedEuropean Pharma Patent DepartmentRamsgate Road Sandwich, Kent CT13 9NJ Sandwich, Kent CT13 9NJ (GB)