(19)

(11)

EP 1 545 591 A2

(12)

(88) Date of publication A3: 07.04.2005 (43) Date of publication: 29.06.2005 Bulletin 2005/26 (21) Application number: 02805684.4 (22) Date of filing: 09.01.2002

(51) International Patent Classification (IPC)7: A61K 38/57, A61K 39/395, A61P 1/04, A61P 17/02 (86) International application number: PCT/US2002/000487 (87) International publication number: WO 2003/065981 (14.08.2003 Gazette 2003/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 18.01.2001 US 262458 P 27.09.2001 US 325233 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: HEUER, Josef, Georg Indianapolis, IN 46231 (US) KIRKLY, Kristine, Kay Fortville, IN 46040 (US) SU, Eric, Wen Carmel, In 46032 (US) (74) Representative: Kent, Lindsey Ruth et al Eli Lilly and Company Limited,Erl Wood Manor,Sunninghill Road Windlesham,Surrey GU20 6PH Windlesham,Surrey GU20 6PH (GB)