(19)

(11)

EP 1 545 608 A2

(12)

(88) Date of publication A3: 04.11.2004 (43) Date of publication: 29.06.2005 Bulletin 2005/26 (21) Application number: 03742272.2 (22) Date of filing: 27.06.2003

(51) International Patent Classification (IPC)7: A61K 39/395, A61K 39/40, A61K 39/42, A61K 39/44, C07K 16/00, C12P 21/08, C07H 21/04 (86) International application number: PCT/US2003/020347 (87) International publication number: WO 2004/002417 (08.01.2004 Gazette 2004/02)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 28.06.2002 US 392431 P (71) Applicant: CENTOCOR, INC. Malvern, PA 19355-1307 (US)

(72) Inventors: HEAVNER, George, A. Malvern, PA 19355 (US) KNIGHT, David, M. Berwyn, PA 19312 (US) GHRAYEB, John Downingtown, PA 19335 (US) SCALLON, Bernard, J. Collegeville, PA 19426 (US) NESSPOR, Thomas, C. Limerick, PA 19468 (US) KUTOLOSKI, Karen, A. Perkiomenville, PA 18074 (US) (74) Representative: Mercer, Christopher Paul et al Carpmaels & Ransford,43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)