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(11)

EP 1 546 087 A1

(12)

(43) Date of publication: 29.06.2005 Bulletin 2005/26 (21) Application number: 03767171.6 (22) Date of filing: 05.08.2003

(51) International Patent Classification (IPC)7: C07C 229/36, C07C 229/28, C07C 229/34, A61K 31/10, A61K 31/195, A61K 31/215, A61P 35/00 (86) International application number: PCT/US2003/024396 (87) International publication number: WO 2004/013085 (12.02.2004 Gazette 2004/07)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 06.08.2002 US 213655 (71) Applicant: Abbott Laboratories Abbott Park,Illinois 60064-6008 (US)

(72) Inventors: BAMAUNG, Nwe, Y. Niles, IL 60714 (US) CRAIG, Richard, A. Racine, WI 53402 (US) HENKIN, Jack Highland Park, IL 60035 (US) KAWAI, Megumi Libertyville, IL 60048 (US) SEARLE, Xenia, B. Grayslake, IL 60030 (US) SHEPPARD, George, S. Wilmette, IL 60091 (US) WANG, Jieyi Lake Bluff, IL 60044 (US) (74) Representative: Modiano, Guido, Dr.-Ing.  Modiano, Josif, Pisanty & Staub,Baaderstrasse 3 80469 München 80469 München (DE)