(19)

(11)

EP 1 546 310 A2

(12)

(88) Date of publication A3: 01.04.2004 (43) Date of publication: 29.06.2005 Bulletin 2005/26 (21) Application number: 03783854.7 (22) Date of filing: 12.08.2003

(51) International Patent Classification (IPC)7: C12N 5/16, A61K 35/14 (86) International application number: PCT/AU2003/001021 (87) International publication number: WO 2004/015056 (19.02.2004 Gazette 2004/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 12.08.2002 US 403131 P 04.12.2002 AU 2002953094 (71) Applicant: THE UNIVERSITY OF QUEENSLAND St Lucia, QLD 4072 (AU)	(72) Inventors: THOMAS, Ranjeny Hawthorne, QLD 4171 (AU) O'SULLIVAN, Brendan, John Kedron, QLD 4031 (AU) (74) Representative: Soames, Candida Jane  D Young & Co120 Holborn London EC1N 2DY London EC1N 2DY (GB)