(19)

(11)

EP 1 546 729 A2

(12)

(88) Date of publication A3: 15.07.2004 (43) Date of publication: 29.06.2005 Bulletin 2005/26 (21) Application number: 03753166.2 (22) Date of filing: 26.09.2003

(51) International Patent Classification (IPC)7: G01N 33/574 (86) International application number: PCT/CA2003/001479 (87) International publication number: WO 2004/029616 (08.04.2004 Gazette 2004/15)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 26.09.2002 US 414314 P (71) Applicant: MOUNT SINAI HOSPITAL TorontoOntario M5G 1X5 (CA)	(72) Inventor: DIAMANDIS, Eleftherios P. Toronto, Ontario M5G 2K2 (CA) (74) Representative: Holliday, Louise Caroline  D Young & Co120 Holborn London EC1N 2DY London EC1N 2DY (GB)